OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic cells), [1] macrophages, [2] and activated B lymphocytes.

OX40 (CD134) and its binding partner, OX40L (CD252), are members of the TNFR/TNF superfamily and are expressed on activated CD4 and CD8 T cells as well as a number of other lymphoid and non-lymphoid cells. Costimulatory signals from OX40 to a ...

The tumour necrosis factor receptor OX40 (CD134) is activated by its cognate ligand OX40L (CD134L, CD252) and functions as a T cell co-stimulatory molecule. OX40-OX40L interactions have been proposed as a potential therapeutic target for treating autoimmunity.

OX40 (CD134) and its binding partner OX40-Ligand (OX40L) represent members of the TNFR and TNF superfamilies that appear to be crucial to many types of immune reaction mediated by T cells. Emerging data have now put these molecules at the forefront of the field of what has been termed T cell costimulation.

2020年3月1日 · The T cell co-stimulatory molecule OX40 and its cognate ligand OX40L have attracted broad research interest as a therapeutic target in T cell-mediated diseases. Accumulating preclinical evidence highlights the therapeutic efficacy of both agonist and blockade of the OX40–OX40L interaction.

OX40 (CD134, TNFRSF4) is a co-stimulatory molecule that is predominantly expressed on activated lymphocytes, especially CD4 + T cells. The expression of OX40 on T cells is induced by TCR stimulation, and augmented by co-stimulation of CD28 and CD40 L [214, 215].

The interaction between OX40 and OX40L (OX40/OX40L) induces the expansion and proliferation of T cells and decreases the immunosuppression of regulatory T (Treg) cells to enhance the immune response to the specific antigen.

When OX40 on activated T cells binds OX40L on antigen-presenting cells, T-cell activation and immune stimulation are initiated via enhanced T-cell survival, proliferation and cytotoxicity, memory T-cell formation, and abrogation of regulatory T cell (Treg) immunosuppressive functions.

2017年3月1日 · The T cell co-stimulatory receptor, OX40 (CD134), and its interacting ligand OX40L (CD252) are members of the tumour necrosis factor receptors/tumour necrosis factor superfamily (TNFRSF/TNFSF) involved in potentiating T cell responses triggered through the T cell receptor (TCR).

2006年2月23日 · OX40 is a T cell costimulator activated by OX40L. Blockade of the OX40L-OX40 interaction has ameliorative effects in animal models of T cell pathologies. In order to better understand the interaction between OX40 and OX40L, we have determined the crystal structure of murine OX40L and of the human OX40-OX40L complex at 1.45 and 2.4 Å, respectively.