12-Oxo-ltb4 | C20H30O4 | CID 5280876 - PubChem
12-Oxo-ltb4 | C20H30O4 | CID 5280876 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
12-Oxo-leukotriene B4 (12-Oxo-LTB4) | 内源代谢物 | MCE
12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC 50 of 33 nM. 12-Oxo-leukotriene B4 ...
12-Oxo-LTB4, a Key Pivotal Intermediate in LTB4 Metabolism
1995年3月1日 · The Total Synthesis of 5-Oxo-12(S)-hydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic Acid and Its 8,9-trans-Isomer and Their Identification in Human Platelets. The Journal of Organic Chemistry 1998, 63 (24) , 8976-8982. DOI: 10.1021/jo9813282.
Metabolism of leukotriene B4 by cultured human ... - ScienceDirect
1993年12月5日 · This pathway involves initial formation of 12-oxo-LTB4 catalyzed by 12-hydroxyeicosanoid dehydrogenase followed by reduction by delta 10-reductase. The most lipophilic metabolite of LTB4 was identified as 10-hydroxy-4,6,12-octadecatrienoic acid which could result from beta-oxidation reactions of LTB4 following reduction of the 10,11-double bond.
Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical …
1997年1月24日 · The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB 4) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB …
美国GlpBio - 12-oxo Leukotriene B4 | Cas# 136696-10-1
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide an
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12-oxo Leukotriene B4 | TargetMol
It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway.
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“清心除热”中药莲子心介导白三烯代谢LTB4DH/12-oxo-LTB4/SH-P…
“清心除热”中药莲子心介导白三烯代谢ltb4dh/12-oxo-ltb4/sh-ptp1轴抗心肌纤维化分子机制. 负责人：程媛媛. 依托单位：广州中医药大学. 批准年份：2020
12-oxo-LTB4在制备抗心肌纤维化损伤药物中的应用 - X技术网
2024年6月6日 · 本发明人团队前期研究《gallic acid-l-leucine (gal)conjugateenhances macrophagephagocytosis via inducing leukotriene b412-hydroxydehydrogenase (ltb4dh)expression》显示，利用没食子酸-l-亮氨酸 (gal)诱导ltb4dh的表达 (同时数据显示ltb4代谢产物12-oxo-ltb4，13,14-dh-oxo-pge2，13,14-dh-oxo-pgf2a量得到提升)能增强巨噬细胞对荧光微球和凋亡h9c2心肌细胞的吞噬作用，及时清除凋亡细胞对消除急性心肌梗死后的持续炎症有利。 …
12-oxo-LTB4在制备抗心肌纤维化损伤药物中的应用 - PatentGuru
2024年2月5日 · 本发明公开了12‑oxo‑LTB4在制备抗心肌纤维化损伤药物中的应用。 具体为，化合物12‑oxo‑LTB4能促进巨噬细胞对凋亡心肌成纤维细胞的吞噬，改善异丙肾上腺素所致小鼠心肌纤维化损伤。