OAS1 Gene - GeneCards | OAS1 Protein | OAS1 Antibody
2024年12月25日 · OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Immunodeficiency 100 With Pulmonary Alveolar Proteinosis …
OAS1 - Wikipedia
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. [5][6] This gene encodes a member of the 2-5A synthetase family, which include essential …
Activation of Oas1a gene expression by type I IFN requires both …
2012年4月10日 · Oas1a is an active synthetase with broad antiviral activity mediated through RNase L. Oas1b is inactive but can inhibit Oas1a synthetase activity and mediate a flavivirus …
2'-5'-寡聚腺苷酸合成酶 1（OAS1）基因 - MCE-生物活性 ...
这种干扰素诱导的基因编码一种合成 2',5'-寡聚腺苷酸 (2-5As) 的蛋白质。 这种蛋白质在先天细胞抗病毒反应中起着关键作用，并与其他细胞过程如细胞生长和细胞凋亡有关。 可变剪接导致 …
Type I interferon sensing unlocks dormant adipocyte ... - Nature
2020年6月2日 · We show that activation of the type I interferon (IFN)/IFNα receptor (IFNAR) axis amplifies adipocyte inflammatory vigor and uncovers dormant gene expression patterns …
OAS cross-activates RNase L intercellularly through cell-to-cell ...
2025年2月25日 · OAS high tumors naturally produce 2-5A that induces antitumor immunity. The 2′,5′-oligoadenylate synthetase (OAS)-RNase L pathway is a classical antiviral innate immune …
Activation of Oas1a gene expression by type I IFN requires ... - PubMed
2012年4月10日 · The murine 2'-5' oligoadenylate synthetase 1a (Oas1a) and Oas1b genes are type 1 IFN responsive genes. Oas1a is an active synthetase with broad antiviral activity …
多组学分析揭示干扰素刺激基因 OAS1 作为泛癌的预后和免疫生物 …
简介OAS1（2'-5'-寡腺苷酸合成酶1）是干扰素刺激基因的成员，在抗病毒过程中发挥着重要作用。 近年来，OAS1在肿瘤中的作用引起人们的关注，并发现它与多种肿瘤的预后相关。 然 …
RIG-I配体通过RIG-I和OAS1/RNase L分别介导的“启动”和“效应”过程 …
2021年7月31日 · 其中， OAS1对3p-RNA显示出最强的亲和力，被激活后，合成第二信使2'-5'寡腺苷酸(2-5A)来激活内切核糖核酸酶RNase L，最终促进RNase L介导的RNA降解过程。 …
Oas1a 2'-5' oligoadenylate synthetase 1A [ (house mouse)]
Gene ID: 246730, updated on 8-Feb-2025. Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in purine nucleotide biosynthetic process. Acts …