2024年12月25日 · OAS1 (2'-5'-Oligoadenylate Synthetase 1) is a Protein Coding gene. Diseases associated with OAS1 include Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia and Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia.

Gene ID: 23960, updated on 8-Feb-2025. This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5.

2025年2月14日 · We demonstrated that Oas1g was identified as a hub ISG in AD and can downregulate the activation of IFN-β and STAT1, reducing the expression of ISGs in neuroinflammation. Oas1g might potentially be a beneficial candidate for both prevention and treatment of AD.

We demonstrated that Oas1g was identified as a hub ISG in AD and can downregulate the activation of IFN-β and STAT1, reducing the expression of ISGs in neuroinflammation. Oas1g might potentially be a beneficial candidate for both prevention and treatment of AD.

2024年12月17日 · View mouse Oas1g Chr5:121014205-121025676 with: phenotypes, sequences, polymorphisms, references, function, expression

这种干扰素诱导的基因编码一种合成 2',5'-寡聚腺苷酸 (2-5As) 的蛋白质。 这种蛋白质在先天细胞抗病毒反应中起着关键作用，并与其他细胞过程如细胞生长和细胞凋亡有关。 可变剪接导致具有不同酶活性的多个转录变体。 该基因的多态性与病毒感染的易感性有关，包括 SARS-CoV-2 和 1 型糖尿病。 该基因位于 12 号染色体上的一组相关基因中。 [RefSeq 提供，2022 年 5 月] This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As).

Gene ID: 4938, updated on 8-Feb-2025. This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis.

2019年10月29日 · Here we identify a frequently used alternative splice site in the gene oligoadenylate synthetase 1g (Oas1g), a key component of the 2–5A antiviral system. Usage of this splice site leads to the generation of a transcript subject to decay, and removal of the site leads to increased expression of Oas1g and an improved antiviral response.

2023年3月16日 · 2’-5’寡聚腺苷酸合成酶（2’-5’ oligoadenylate synthetase , OAS）是一类广谱抗病毒蛋白，包括4个成员：OAS1-3和OASL，是抗病毒天然免疫中的关键效应因子。 OAS能够识别不同长度的dsRNA以激活RNaseL以降解病毒基因组并放大RIG-I介导的抗病毒天然免疫效应。...

方法采用TCGA分析OAS1在泛癌中的表达、预后价值、遗传改变、选择性剪接事件、GTEx、HPA、GEPIA 和 OncoSplicing 数据库。 使用 ESTIMATE、xCell、CIBERSORT 和 QUANTISEQ 算法评估 OAS1 相关的免疫细胞浸润。 使用 TISH 数据库下载单细胞转录组数据。 最后，在两种胰腺癌细胞中研究了 OAS1 对细胞凋亡、迁移和侵袭的作用。 结果我们的结果揭示了各种肿瘤中 OAS1 表达的显着差异，这具有预后意义。 此外，我们还研究了 OAS1 对不同类型癌症的基因 …