2024年12月29日 · The +1 PRF of OAZ1 mRNA is stimulated by polyamines, serving as a critical feedback mechanism in polyamine synthesis regulation. When polyamine levels are elevated, the +1 PRF results in the expression of full-length OAZ1, which inhibits ODC and extracellular polyamine uptake [ 29 ].

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene. [5] [6] [7] Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by ...

2020年6月16日 · Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human...

2024年12月25日 · OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and DREAM Repression and Dynorphin Expression. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity.

Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells. To further understand its functions in CML pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development.

2011年9月7日 · Here we used S. cerevisiae OAZ1 to dissect the enigmatic mechanism underlying polyamine regulation of RFS. In contrast with previous assumptions, we report here that the nascent antizyme...

2024年1月28日 · However, intriguingly in humans, except for retrotransposon-derived genes (45, 82), only one case with strong evidence has been documented, i.e. +1PRF in OAZ1, which produces functional OAZ1 to down-regulate polyamine levels .

2018年9月20日 · The stop codon of OAZ1, serving as the +1 PRF site, appears to be a dividing point for “sticky” codon composition in frame 2. Since frame 2 becomes frame 1 after +1 PRF, this result supports the view that codon optimization is highly coordinated between general coding regions and specific PRF signals.

2025年1月4日 · Title: Assay of OAZ1 mRNA levels in chronic myeloid leukemia combined with application of leukemia PCR array identified relevant gene changes affected by antizyme. Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders.

2006年7月12日 · The interplay between polyamine concentration and frameshifting acts as a homeostatic mechanism to maintain appropriate polyamine concentration in the cell. The S. cerevisiae OAZ1 gene is a member of this family and employs a +1 shifty stop frameshift for its expression (Palanimurugan et al. 2004).