2025年3月13日 · Obi's argument invokes the “law of the case” doctrine. Derived to promote both consistency and efficiency over a case's lifespan, this longstanding rule commands that “findings made at one stage in the litigation should not be reconsidered at subsequent stages of …

2019年12月20日 · Obi claims the district court improperly admitted the medical testimony for two reasons: (1) the doctors made unfounded assumptions about Lares’s prior drug use and (2) the doctors lacked personal knowledge of the case.

2020年10月1日 · Occult hepatitis B infection (OBI) refers to a condition where replication-competent HBV DNA is present in the liver, with or without HBV DNA in the blood, in individuals with serum HBsAg negativity assessed by currently available assays. The episomal covalently closed circular DNA (cccDNA) in OBI is in a low replicative state.

Occult hepatitis B virus (HBV) infection (OBI) is a challenging pathobiological and clinical issue that has been widely debated for several decades. By definition, OBI is characterized by the persistence of HBV DNA in the liver tissue (and in some cases also in the serum) in the absence of circulating HBV surface antigen (HBsAg).

Occult hepatitis B virus (HBV) infection (OBI) refers to a condition in which replication-competent viral DNA is present in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surface antigen (HBsAg).

2024年9月15日 · Occult hepatitis B infection (OBI) refers to the presence of replication-competent hepatitis B virus (HBV) DNA in the liver, even when HBV DNA is not detectable in the blood using standard assays.

OBI or reactivated HBV infections often lead to selection of HBsAg escape mutations as we could show in 11 of 14 cases. Infection of vaccinated individuals favors development of OBI as we observed in 6 blood donors.

2020年11月23日 · In seropositive OBI, cases can arise as two scenarios: (1) the clearance of an acute self-limiting HBV infection or (2) the seroclearance of HBsAg after chronic infection. In the first scenario, OBI is often seen in cases of concomitant liver diseases, cryptogenic cirrhosis, or hepatocellular carcinoma (HCC) who had previously been infected and ...

2017年12月18日 · Results: OBI was found in 27/78 patients (34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery (average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases ( P = 0.0057).

Hepatitis B virus (HBV) occult infection (OBI) is a risk factor to be taken into account in transfusion, hemodialysis and organ transplantation. The aim of this study was to identify and characterize at the molecular level OBI cases in patients with end-stage liver disease.