Occult hepatitis B virus (HBV) infection (OBI) refers to a condition in which replication-competent viral DNA is present in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surface antigen ...

Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of HBV DNA in the absence of detectable hepatitis B surface antigen. Since OBI was first described in the late 1970s, there has been increasing interest in this topic.

2011年4月21日 · Occult hepatitis B virus (HBV) infection (OBI), alternatively defined as occult hepatitis B (OHB), is a challenging clinical entity. It is recognized by two main characteristics: absence of HBsAg, and low viral replication.

2024年9月15日 · Occult hepatitis B infection (OBI) refers to the presence of replication-competent hepatitis B virus (HBV) DNA in the liver, even when HBV DNA is not detectable in the blood using standard assays. During this phase of chronic HBV infection, the HBV genomes exist as episomal covalently closed circular DNA (cccDNA) and exhibit low replication ...

Occult hepatitis B infection (OBI) refers to a condition where replication-competent HBV DNA is present in the liver, with or without HBV DNA in the blood, in individuals with serum HBsAg negativity assessed by currently available assays.

2025年3月1日 · Individuals chronically infected with the hepatitis B virus (HBV) are at increased risk of developing cirrhosis, and HBV infection is the leading cause of hepatocellular carcinoma (HCC) worldwide. 1 Chronic HBV infection is associated with significant morbidity and mortality globally, with 1,100,000 deaths per year globally due to HBV-related ...

2013年3月4日 · Occult HBV infection (OBI) is defined as HBV DNA detection in serum or in the liver by sensitive diagnostic tests in HBsAg-negative patients with or without serologic markers of previous viral exposure. OBI seems to be higher among subjects at high risk for HBV infection and with liver disease.

5 天之前 · Occult hepatitis B infection (OBI) is a serious public health issue. Although a number of effective hepatitis B vaccines are available, hepatitis B still poses a threat to global public health. Patients with OBI are usually asymptomatic, but there may be active HBV DNA present in their blood, leading to the risk of virus transmission during …

2022年7月8日 · Occult hepatitis B virus (HBV) infection (OBI) refers to a condition in which replication-competent viral DNA is present in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surface antigen (HBsAg).

Occult hepatitis B virus (HBV) infection (OBI) is recognized as one of the possible phases in the natural history of chronic HB V infection [1]. OBI defines the persistence of HBV genomes in the hepatocytes of individuals testing negative for HBV surface antigen (HBs Ag) and, usually, also for serum HBV DNA [2].