2014年3月6日 · ODR-8/UfSP2 and ODR-4 are expressed in the same set of twelve chemosensory neurons, and physically interact at the ER membrane. ODR-4 also binds ODR-10, suggesting that an ODR-4/ODR-8 complex promotes GPCR folding, maturation, or …

1998年5月1日 · Other cilia-signaling proteins, including ion channels, a Gα protein, and even other receptor types, are localized via an odr-4/odr-8 –independent pathway. odr-4 encodes a novel membrane protein that is expressed exclusively on intracellular membranes of chemosensory neurons, where it acts cell-autonomously to facilitate odorant receptor folding...

2024年6月21日 · However, there is controversy over the function of UFSP2 in GPCR transport with one report suggesting that ODR8, Caenorhabditis elegans homolog of UFSP2, modulates the surface localization of some olfactory receptors in chemosensory neurons in an activity- and UFM1-independent manner . Furthermore, we cannot exclude the possibility that the ...

Gene ID: 177417, updated on 8-Feb-2025. Enables deUFMylase activity. Involved in several processes, including positive regulation of chemotaxis; protein localization to non-motile cilium; and response to ethanol. Part of protein-containing complex. Is expressed in hypodermis; intestine; and nervous system.

2020年5月9日 · CAR expression level and stability on the T cell were greatly affected by transmembrane rather than hinge domain. Antigen-specific functions of most CAR-T cells depended on their CAR expression levels. However, CARs with a CD8α- or CD28-derived hinge domain showed significant differences in CAR-T cell function, despite their equal expression ...

2014年3月1日 · Here, we show that odr-8 encodes the C. elegans ortholog of Ufm1-specific protease 2 (UfSP2). UfSPs are cysteine proteases identified biochemically by their ability to liberate the ubiquitin-like...

2014年3月1日 · ODR-8/UfSP2 and ODR-4 are expressed in the same set of twelve chemosensory neurons, and physically interact at the ER membrane. ODR-4 also binds ODR-10, suggesting that an ODR-4/ODR-8 complex promotes GPCR folding, maturation, or …

2014年3月6日 · ODR-8/UfSP2 and ODR-4 are expressed in the same set of twelve chemosensory neurons, and physically interact at the ER membrane. ODR-4 also binds ODR-10, suggesting that an ODR-4/ODR-8 complex promotes GPCR folding, maturation, or …

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