胡晋川/钱茂祥课题组《Nucleic Acids Research 》合作开发单碱基 …
2021年11月15日 · 作者分析了OG损伤与局部GC含量、染色质状态以及基因分布的关系，发现在GC富集的转录起始位点附近OG反而比较少，且OG与G4结构的分布具有负相关性；另一方 …
Genomic 8-oxoguanine modulates gene transcription …
2025年2月1日 · 8-oxo-7,8-dihydroguanine (OG) is one of the most abundant oxidative lesions in the genome and is associated with genome instability. Its mutagenic potential is counteracted …
Crosstalk between G-quadruplex and ROS | Cell Death & Disease
2023年1月18日 · The ROS in cancer cells oxidizes guanine residues in the oncogene promoter region or mRNA G4s to OG, which activates the G4-mediated DDR pathway and translation.
G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome …
2022年9月17日 · In this review, we summarize recent advantages about genome-wide mapping of G4 and OG, and discuss their crosstalk at genomic level. G-quadruplex (G4) is a non …
G-quadruplex DNA and RNA: Their roles in regulation of DNA …
2020年10月8日 · ROS-mediated oxidation of DNA (yielding 8-oxo-7,8-dihydroguanine [OG] in gene promoters) is a signaling agent for gene activation. When OG is formed in guanine-rich, …
Oxidative Damage Induces a Vacancy G-Quadruplex That Binds
2022年4月13日 · G-quadruplex (G4)-forming sequences in gene promoters are highly susceptible to G-oxidation, which can subsequently cause gene activation. However, the underlying G4 …
氧化损伤诱导结合鸟嘌呤代谢物的空位 G-四链体：氧化 BLM 基因 …
For the first time, we show that OG can induce a G-vacancy-containing G4 (vG4), which can be filled in and stabilized by guanine metabolites and derivatives. We determined the NMR …
Interplay of guanine oxidation and G-quadruplex folding in gene ...
Oxidation of DNA by ROS drives conversion of G to 8-oxo-7,8-dihydroguanine (OG) to mark target promoters for base excision repair initiated by OG-glycosylase I (OGG1). Sequence …
DNA G-quadruplex structures: more than simple roadblocks to ...
Specific G4 topologies can be formed and include anti-parallel, parallel and hybrid structures, depending on the relative orientation of the DNA strand within the structure. Intermolecular G4 …
G4-Ligand-Conjugated Oligonucleotides Mediate Selective …
2024年3月2日 · Here, we developed a strategy to selectively target an individual G4 DNA structure. The strategy is based on a ligand that binds and stabilizes G4s without selectivity, …