2022年4月30日 · Here, we report the 2.92 Å resolution cryo-electron microscopy (EM) structure of its E1 component 2-oxoglutarate dehydrogenase (OGDH). The density map comprised residues 129–1,023, which is nearly the full length of OGDH. The structure clearly shows the active site and Ca2+ binding site of OGDH.

Light promotes nuclear targeting of the TCA cycle–associated enzyme KGDH to regulate histone demethylation by JMJs in plants. Most KGDH subunits, including OGDH1, E2, and E3, are targeted to mitochondria to form a holoenzyme for α-KG decarboxylation in the TCA cycle. Light exposure promotes a small portion of KGDH entering into the nucleus.

2024年9月27日 · Moreover, we analyzed and validated the interactions between each subunit, and determined the flexible binding mode for E1o, E2o and E3, resulting in a proposed model of Sus scrofa OGDHc....

2024年11月1日 · The alpha-keto glutarate dehydrogenase complex (KGDH) belongs to the mitochondrial alpha-keto acid dehydrogenase family and consists of multiple copies of 3 subunits: 2-oxoglutarate dehydrogenase (OGDH, E1), dihydrolipoyl succinyltransferase (DLST, E2), dihydrolipoamide dehydrogenase (DLD, E3) [1].

Pyruvate dehydrogenase (PDH), branched-chain 2-oxo acid dehydrogenase (BCDH) and 2-oxoglutarate dehydrogenase (OGDH) are multienzyme complexes that play crucial roles in several common metabolic pathways.

2023年7月7日 · We report that the E1 subunit of 2-Oxoglutarate Dehydrogenase (OGDH/E1), a crucial enzyme in the tricarboxylic acid (TCA) cycle, is recognized by the LIM domains of Zasp. OGDH/E1 is recruited to the growing Z-disc in addition to its mitochondrial localization, and its function is required for myofibril growth and assembly.

2023年7月14日 · 何跃辉团队通过正向或反向遗传学方法获得了 拟南芥 KGDH两个亚基E1（oxoglutarate dehydrogenase, OGDH1和OGDH2）和E2（dihydrolipoamide succinyltransferase, E2a和E2b）的功能缺失突变体。

The presence of DHTKD1 and OGDH, two enzymes with overlapping and specific substrate specificities, in a single complex with the shared E2 and E3 components, and possibly GCDH increases the complexity of the enzyme complex, but could offer additional possibilities to coordinate metabolic flux in the TCA cycle and the lysine degradation pathway.

2023年7月16日 · OGDH、E2和E3分别催化α-KG脱羧、琥珀酰辅酶A生成和二氢脂酰胺脱氢。 在拟南芥中，E1亚基OGDH由OGDH1和OGDH2两个基因编码。 据报道，假定的OGDH功能丧失突变体 (OGDH1和OGDH2功能均丧失)与野生型 (WT)相比，细胞总α-KG水平保持不变。

2024年12月25日 · The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific …