2024年12月25日 · OLIG1 (Oligodendrocyte Transcription Factor 1) is a Protein Coding gene. Diseases associated with OLIG1 include Oligodendroglioma and Anaplastic Oligodendroglioma. Among its related pathways are Oligodendrocyte specification and differentiation, leading to myelin components for CNS and Neural crest differentiation.

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene. [5] [6]

2015年3月11日 · The current studies analyzed the function of Olig1 in oligodendrocyte differentiation and developmental myelination in brain. Both oligodendrocyte progenitor cell commitment and oligodendrocyte differentiation were impaired in the corpus callosum of Olig1 -null mice, resulting in hypomyelination throughout adulthood in the brain.

2004年12月17日 · We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis. The oligodendrocyte is the myelinating cell of the central nervous system (CNS) (1, 2).

2025年2月8日 · Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility; This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states.

2024年7月23日 · Fu et al. develop a method that can isolate spinal motor neurons with different regenerative capability after injury and reveals factors with differential expression. They focus on the functional analysis of Olig1, a transcription factor that determines early neural patterning, and reveal its effects on axonal regeneration in various models.

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。 预计通过 RNA 聚合酶 II 参与神经元分化和转录调节。 预计在神经元命运承诺的上游或内部行动。 预测是染色质的一部分。 预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity.

Oligodendrocyte transcription factor 1 (Olig1) is important for the maturation of OPCs and the repair of demyelinated lesions. However, how Olig1 modulates the development of OPCs or the remyelination associated with ischemic injury remains unclear.

Olig1和Olig2是Olig家族主要成员,近年来研究发现Olig1和Olig2与脱髓鞘疾病、胶质瘤、缺血缺氧性脑损伤等疾病的发生及恢复密切相关,它们不仅参与了少突胶质早期定向分化和晚期成熟分化的转录调控过程,而且对中枢神经系统的正常发育及髓鞘的形成有着至关重要的 ...

目的少突胶质细胞(OL)发育分化是在一系列转录因子调控下,历经少突胶质细胞前体细胞(OPC),幼稚OL和成熟OL等典型的形态和功能演变完成.转录因子Olig2和Olig1分别在OPC早期定向分化和OL的成熟分化中扮演了关键的角色,但其确切作用和调控机制尚不清楚.本研究目的 ...