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Sample Prep. with SPE LC-HRMS & HRMS/MS - SCIEX
As mentioned above, HRMS is an attractive platform for the analysis of oligonucleotides as it is well suited towards sensitive bioanalysis and enables the ability to detect and quantify impurities/metabolites within the sample. Additionally the full scan MRMHR data can be …
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- High Resolution Analysis of Synthetic Oligonucleotides
- Characterization of oligonucleotides and related impurities to ... - SCIEX
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What is Oligonucleotide Synthesis?
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How Does It Work? | Oligonucleotide Therapies
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Treating Disease at the RNA Level with Oligonucleotides
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What are oligonucleotide therapeutics, and how do they work?
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ScienceDirect
https://www.sciencedirect.com › science › article › pii
Analytical characterization of DNA and RNA oligonucleotides by ...
2021年7月5日 · In this study, we developed a generic HILIC hyphenated with high-resolution mass spectrometric (HILIC−HRMS) method to provide rapid, robust, and in-depth analytical …
- 作者: Ming Huang, Xiaobin Xu, Haibo Qiu, Ning Li
- Publish Year: 2021
SCIEX
https://sciex.com › content › dam › SCIEX › pdf › tech-notes › ...
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High Resolution Analysis of Synthetic Oligonucleotides
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Oligonucleotides HRMS 的研究
ScienceDirect
Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti-sense oligonucleotides and small interfering RNAs (siRNAs). In this study, we developed a generic hydrophilic interactio...
已发布: 2021/07/05
Cited By: 0
Keywords: Oligonucle…
PubMed
Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry
Liquid chromatography-mass spectrometry has been widely implemented as a powerful tool for providing in-depth characterization of nucleic acid therapeutic modalities, such as anti-sense oligonucleotides and small interfering RNAs (siRNAs). In this study, we developed a generic hydrophilic interactio...
作者: Ming Huang
已发布: 2021/07/05
Keywords: Hydrophili…
PubMed
Oligonucleotide quantification and metabolite profiling by high-resolution and accurate mass spectrometry
Aim: Advancements in RNA interference therapeutics have triggered development of improved bioanalytical methods for oligonucleotide metabolite profiling and high-throughput quantification in biological matrices. Results & methodology: HPLC coupled with high-resolution mass spectrometry (LC-HRMS) met...
作者: Ju Liu
已发布: 2019/11
Keywords: RNAi; mas…
ScienceDirect
Metabolite profiling of chemically modified oligonucleotides in rat liver homogenates using hydrophilic interaction liquid chromatography-high resolution mass spectrometry
Chemically modified oligonucleotide is a rapidly emerging field of biotherapeutics. The evaluation of the metabolic stability of therapeutic oligonucleotides is critical. The current methods are limited to the ion-pairing reversed phase chromatographic techniques. Due to complex chemical modificatio...
已发布: 2024/07/01
Cited By: 0
Keywords: Oligonucle…
ScienceDirect
The use of high-resolution mass spectrometry (HRMS) for the analysis of DNA and other macromolecules: A how-to guide for forensic chemistry
High-resolution mass spectrometry (HRMS) is a highly effective technique for the analysis of DNA and other biological macromolecules and has the potential to be a valuable tool for forensic chemists. In this work, we introduce concepts of HRMS, discuss benefits of the technique, and outline the step...
已发布: 2019/06/01
Cited By: 0
Keywords: Matrix asse…
ACS Publications
https://pubs.acs.org › doi
Decoding Complexity in Synthetic Oligonucleotides: …
2023年12月29日 · Herein, we present a direct method employing fully resolved isotopic envelopes, enabled by high resolution mass spectrometry (HRMS), to identify and quantify isobaric impurity ions resulting from the deletion or …
thermofisher.com
https://assets.thermofisher.com › TFS-Assets › CMD › Application-Notes
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Identification and quantitation of oligonucleotides, impurities, …
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Waters Corporation
https://www.waters.com › nextgen › hr › en › library › ...
HRMS Quantitation of Oligonucleotides Using Xevo G2-XS QTof …
HRMS enables characterization (identifying different isotopes/charge states) of an oligonucleotide molecule and the ability to select isotope/charge state best suited to achieve good sensitivity, …
其他用户还问了以下问题
Why should you use HRMS for oligonucleotides analysis?
As mentioned above, HRMS is an attractive platform for the analysis of oligonucleotides as it is well suited towards sensitive bioanalysis and enables the ability to detect and quantify impurities/metabolites within the sample.
Sample Prep. with SPE LC-HRMS & HRMS/MS - SCIEX
sciex.com
How LC-HRMS is used in the analysis of Oligonucleotide Therapeutics?
Figure 1. A schematic representation of the HRMS workflow. high resolution mass spectrometry (LC-HRMS) is an attractive technique for the analysis of oligonucleotide therapeutics. LC-HRMS can effectively discriminate and quantify not only the target analyte but also impurities/metabolites in the sample.
Sample Prep. with SPE LC-HRMS & HRMS/MS - SCIEX
sciex.com
What is the objective of oligonucleotide mass measurement?
Frequently the objective of intact mass measurement is confirmation of the target mass for a specific oligonucleotide sequence. In addition, there may be a need to identify failure sequences or impurities which are present in a sample. A common tool for this processing is ProMass which enables batch processing of oligonucleotide data.
High Resolution Analysis of Synthetic Oligonucleotides - SCIEX
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Why do oligonucleotides hold high promise?
In particular, these therapies hold high promise due to their specificity and the high potential for treating previously undruggable targets. A defining characteristic of oligonucleotides, when compared to more commonly used protein based biotherapeutics, is that they are produced synthetically.
High Resolution Analysis of Synthetic Oligonucleotides - SCIEX
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Which data processing software is used for oligonucleotide analysis?
For the purpose of high throughput oligonucleotide analysis to verify purity and mass confirmation a common data processing solution is ProMass from Novatia LLC. This software enables rapid verification of molecular mass and assessment of purity.
High Resolution Analysis of Synthetic Oligonucleotides - SCIEX
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Can oligonucleotide sequence information be pasted?
To expedite entry, values may be pasted from other sources such as Excel. The software is able to use defined oligonucleotide sequence information, calculate the theoretical mass sequence and, if selected, the associated failure sequences from both the 5’ and 3’ ends during ProMass processing.
High Resolution Analysis of Synthetic Oligonucleotides - SCIEX
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Analytical characterization of DNA and RNA oligonucleotides by ...
2021年7月5日 · High-resolution mass spectrometric (HRMS) analysis was used to determine the deconvoluted masses of oligonucleotide and siRNA standards and their impurities. To enable …
Food and Drug Administration (.gov)
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In-Depth Impurity Assessment of Synthetic Oligonucleotides …
•Synthetic oligonucleotides, as an evolving class of therapeutics, pose unique scientific and regulatory challenges. •In-depth impurity assessment offers comprehensive impurity
PubMed
https://pubmed.ncbi.nlm.nih.gov
Oligonucleotide quantification and metabolite profiling by high ...
Results & methodology: HPLC coupled with high-resolution mass spectrometry (LC-HRMS) methods were developed to investigate the metabolism of a REVERSIR™ molecule in vivo. …
Waters Corporation
https://www.waters.com › content › dam › waters › en › app-notes
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HRMS Quantitation of Oligonucleotides Using Xevo G2-XS …
In the area of oligonucleotides, HRMS in particular has been increasingly utilized.1 In this application note, we outline the performance capabilities of the Xevo G2-XS QTof HRMS …
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