Omomyc 将 MYC 隔离在无法结合 DNA 的蛋白质二聚体中，同时还与 MAX 形成同二聚体和异二聚体，MAX 占据具有转录非活性蛋白质复合物的 E-box，从而阻止 MYC 靶标的转录。

2022年9月23日 · Myc operates in a network with its heterodimerization partner Max, the latter of which can form homodimer and heterodimer. Omomyc, a polypeptide, can block Myc to treat cancers because it can both homodimerize as efficiently as …

2025年2月19日 · Omomyc is a 91 amino acid mini-protein that works as a MYC dominant negative and achieved a dramatic therapeutic impact in tumours, while causing only mild and reversible side effects in normal...

Max Alexander Osaze Ojomoh (born 14 September 2000) is an English professional rugby union player who plays as a centre for Premiership club Bath Rugby. [1] Max Ojomoh was born in Bath, Somerset on 14 September 2000. He is the son of former Bath Rugby and England player, Steve Ojomoh. Ojomoh was educated at King Edward's School, Bath. [2]

2019年10月28日 · Taken together, our data suggest that the mechanism of action of Omomyc is to bind DNA as either a homodimer or a heterodimer with Max that is formed cotranslationally, revealing a novel mechanism to inhibit the MYC oncogene.

2023年5月31日 · OMO-103是基于Omomyc衍生化的细胞穿膜肽，2021年4月启动了一项针对晚期实体瘤的I期临床试验，用以评估其安全性、PK及有效性（NCT04808362）。 入组的病人包括胰腺癌、肠癌和非小细胞肺癌等实体瘤病人，剂量从0.48 mg/kg爬坡到9.72 mg/kg，每周一次注射给药，RP2D=6.48mg/kg。 截至到2022.10.10，给药9周后进行CT扫描的12名患者中，有8例病人中初步看到有效性（SD，stable disease），DLT是胰腺炎，其他不良反应多与静脉输液相关，安 …

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