
Bacterial outer membrane vesicles as a platform for biomedical ...
2020年7月10日 · Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components.
Engineering bacterial outer membrane vesicles as transdermal ...
2020年7月3日 · Here, we developed the outer membrane vesicles derived from transgenic Escherichia coli, modified with α v β 3 integrin peptide targeting ligand and indocyanine green (named as I-P-OMVs), to induce the transdermal photo-TRAIL-programmed treatment in skin melanoma.-OMVs, which are outer membrane vesicles derived from transgenic Escherichia ...
外膜囊泡的物质传递及细菌保护作用研究进展
2024年2月3日 · 摘要:外膜囊泡 (outer membrane vesicles, OMVs)是一种直径为10−250 nm的球状结构,由革兰氏阴性菌分泌。 OMVs已逐渐被认为是一种新型的分泌系统,它能运输脂质、蛋白质、核酸、细胞毒素和信号分子等不同物质,具有多种生物学功能,包括细菌与细菌之间的交流、致病因子传递、抵抗外界不良环境和调节免疫反应等。 近年来,细菌OMVs基于生物特征介导的抗生素耐药性传递与OMVs的应用潜能逐步受到重视。 本文旨在对细菌OMVs的来源与物质传递 …
Outer membrane vesicles from Escherichia coli are efficiently ...
2023年2月1日 · Negative stained transmission electron microscopy (TEM) was used to visualize the OMVs particles. OMVs samples (10 μl) was added dropwise on the copper grids and precipitated for 1 min before blotting off the excess liquid with filter paper.
Bacterial outer membrane vesicles-based therapeutic platform …
2023年2月1日 · We demonstrate that systemic injection of the DOX/Ce6-OMVs@M therapeutic platform, providing combinational photodynamic/chemo-/immunotherapy, eradicates triple-negative breast tumors in mice without side effects. Importantly, this strategy also effectively prevents tumor metastasis to the lung.
Bacterial outer membrane vesicle based versatile nanosystem
2023年3月25日 · Herein, we fabricate a versatile nanosystem for efficient tumor immunotherapy by synergizing the efferocytosis blockade-induced secondary necrosis with the bacterial outer membrane vesicles...
Molecular imaging of bacterial outer membrane vesicles based on ...
2023年10月31日 · Bacterial outer membrane vesicles (OMVs) are nano-sized extracellular vesicles (EVs) released by Gram-negative bacteria into their environment. Various mechanisms...
A preparation of bacterial outer membrane with osmium
2023年11月24日 · Biological nanoparticles, such as bacterial outer membrane vesicles (OMVs), are routinely characterized through transmission electron microscopy (TEM). In this study, we report a novel method to prepare OMVs for TEM imaging. To preserve vesicular shape and structure, we developed a dual fixation pro …
Protein-enriched outer membrane vesicles as a native platform …
2018年4月5日 · Here, we utilize outer membrane vesicles (OMVs) released from Escherichia coli to study outer membrane proteins (Omps) in the native membrane environment. Enriched in the...
Bacterial membrane vesicles: formation, functions, and roles in ...
2024年9月21日 · Outer membrane vesicles (OMVs) are nano-sized vesicles actively released by Gram-negative bacteria, playing a crucial role in bacterial survival and interactions with phages. This review focuses on OMVs and succinctly delineates the stimuli instigating OMV formation, their functional repertoire, and their involvement in bacterial-phage interplays.