2019年7月7日 · Recent studies have shown that GPCRs can contribute to the many facets of tumorigenesis, including proliferation, survival, angiogenesis, invasion, metastasis, therapy resistance, and immune evasion. Indeed, GPCRs are widely dysregulated in cancer and yet are underexploited in oncology.

In this systematic review we explored the clinical impact of onco-virotherapy compared to other cancer therapies by analyzing factors such as trial design, patient background, therapy design, delivery strategies, and study outcomes. For this purpose, we retrieved clinical studies from three platforms: ClinicalTrials.gov, PubMed, and EMBASE.

2024年11月1日 · We analyzed the impact of OFO class on postoperative surgical outcomes using Cox proportional-hazards models with hazard ratios (HR) or logistic regression with odds ratios (OR), followed by specific subgroup analyses. We developed a risk model to predict OFO class preoperatively using logistic regression.

2019年11月28日 · Non-small cell lung cancer (NSCLC) is frequently associated with oncogenic driver mutations, which play an important role in carcinogenesis and cancer progression.

2021年12月17日 · Onco-virotherapy is a promising form of immunotherapy for the treatment of cancer. In this review we evaluated the clinical impact of onco-virotherapy for cancer patients who received virotherapy in comparison with cancer patients who received other therapies by means of a systematic analysis.

2025年1月1日 · In summary, the philosophy of onco-functional balance must still be developed in glioma, based on a complex, over changing pluri-modal and personalized equation which should perpetually be solved to anticipate several steps ahead a multistage medico-surgical strategy adapted over time to each human being according to his/her own evolution.

2018年10月3日 · In summary systems biology models driven by multi-OMICS data may help to increase the onco-drug efficacy and overcome the chemo-/immunotherapy resistance phenotype of cancer cells rendering them vulnerable to targeted therapies and ultimately in improving the quality of life of patients.

§癌基因分为：病毒癌基因（v-onco）和细胞癌基因（c-onco）又称原癌基因（protooncogene） §抑癌基因（tumor suppressor gene，antioncogene）编码的蛋白质，其功能是正常细胞增殖过程中的负调控因子，在细胞周期的检验点上起阻止周期进程的作用，或者是促进细胞凋亡。

We therefore developed a novel onco-functional outcome (OFO) classification and evaluated its benefit in subgroups based on age, preoperative neuro-logical morbidity (NIHSS), and Karnofsky Performance Score (KPS).

We propose to establish an interdisciplinary functional onco-imaging pre- center where a broad spectrum of researchers including imaging scientists, microbiologists, chemists, clinical scientists among others will exchange ideas and collaborate with each other to advance the field of cancer research and clinical practice.