2017年6月1日 · IHC analysis of connexin 37 showed impaired gap junctions between oocytes and granulosa cells. IHC staining of the cell proliferation marker PCNA indicated that the proliferation of granulosa...

We demonstrate that postnatal KIT is crucial for oocyte survival, normal folliculogenesis, antral follicle formation and growth, as well as ovarian hormonal secretion, surpassing its role in oocyte activation.

In addition to FF, OS evidence can be consolidated with protein evaluation via immunohistochemistry (IHC). Our review included the study that extended the OS evaluation via IHC. The reported proteins were heat shock proteins (Hsp)—Hsp70, transforming growth factor-beta (Tgf-β)—Tgf-β1, and Notch1.

2023年10月20日 · Checkpoint kinase 2 (CHEK2) deficiency prevents elimination of oocytes in primordial follicles in female mice exposed to radiation and preserves their ovarian function and fertility. Here, we demonstrate that CHEK2 also coordinates the elimination of oocytes after exposure to standard-of-care chemotherapy drugs.

2018年10月18日 · Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be triggered by defects in chromosome synapsis and recombination, which involve repair of DNA double-strand breaks (DSBs) between homologous chromosomes. We show that RNF212, a SUMO ligase required for crossing over, also mediates oocyte quality control.

2019年12月16日 · Here, we demonstrate that luteinizing hormone (LH) surge-induced histone deacetylase 3 (HDAC3) downregulation in GCs is essential for oocyte maturation. Before the LH surge, HDAC3 is highly...

2024年3月6日 · an oocyte marker which stains the cytoplasm of all oocytes, has critical role in early mammalian development, and may be involved in the determination of the animal pole of the oocyte and in the establishment of the inner cell mass and …

2018年12月20日 · Oocyte-GC bidirectional communications via signal transduction or direct cell-to-cell contact provide the molecular and structural basis for effective oocyte-GC crosstalk, which is required for adequate follicular development.

2016年8月8日 · Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their growth. The forkhead transcription factor Foxo3 controls reawakening downstream of PI3K-AKT signaling. However, the identity of the presumptive upstream cell surface receptor controlling the PI3K-AKT-Foxo3 axis has been questioned.

2022年10月5日 · Deficiency of BNC1 results in premature follicular activation and excessive follicular atresia. Mechanistically, BNC1 deficiency triggers oocyte ferroptosis via the NF2-YAP pathway. We...