2021年3月14日 · 血脑屏障（blood-brain barrier，BBB）是药物脑靶向递送的最主要屏障，聚焦超声和微泡联合应用为跨BBB脑靶向递送提供了一种新途径，其主要机制为空化效应。

2020年10月6日 · Focused ultrasound (FUS) in combination with microbubbles can non-invasively open the BBB in a targeted manner. Bolus intravenous injections of microbubbles are standard...

2022年8月30日 · Focused ultrasound (FUS) combined with microbubbles can enhance permeability of BBB and is often performed under MRI guidance. We present an all-ultrasound system capable of targeting desired...

2019年9月26日 · We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MRgFUS-induced BBB opening in eloquent primary motor cortex in four volunteers with amyotrophic...

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2022年11月4日 · Objective: MRI-guided low-intensity focused ultrasound (FUS) has been shown to reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents noninvasively to target brain regions in patients with Alzheimer's disease (AD) and other neurodegenerative conditions.

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