Opsin-5, also known as G-protein coupled receptor 136 or neuropsin is a protein that in humans is encoded by the OPN5 gene. Opsin-5 is a member of the opsin subfamily of the G protein-coupled receptors .

2024年12月25日 · OPN5 (Opsin 5) is a Protein Coding gene. Diseases associated with OPN5 include Cycloplegia. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 11-cis retinal binding.

2020年9月2日 · Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light 1, 2. In mice, OPN5 is a known photoreceptor in the retina 3 and skin 4 but is also...

动物视蛋白家族中的视蛋白 5 (Opn5) 组包含多种相关蛋白，例如 Opn5m，一种在包括哺乳动物在内的所有脊椎动物谱系中保守的蛋白，以及在非哺乳动物脊椎动物基因组中发现的其他成员，如 Opn5L1 和 Opn5L2，以及Opn6 存在于非兽类脊椎动物基因组中，Opn5 同源物也 ...

2022年4月1日 · Here we present the human Neuropsin (hOPN5) for specific and repetitive manipulation of G q signaling in vitro and in vivo with high spatio-temporal resolution. Properties and G protein specificity...

2011年10月17日 · OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner. Immuno-blotting analyses of mouse tissue extracts identified the retina, the brain and, unexpectedly, the outer ears as the major sites of OPN5 expression.

2024年3月1日 · The Opsin 5 (Opn5) group within the animal opsin family comprises a diverse array of related proteins, such as Opn5m, a protein conserved across all vertebrate lineages including mammals, and other members like Opn5L1 and Opn5L2 found in non-mammalian vertebrate genomes, and Opn6 found in non-therian vertebrate genomes, along with …

2019年10月21日 · Here, we assess the function of a population of melanocyte precursor cells in hair and vibrissal follicles that express the photopigment neuropsin (OPN5). Organotypic cultures of murine outer ear and vibrissal skin entrain to a light-dark cycle ex vivo, requiring cis-retinal chromophore and Opn5 gene function.

2003年11月20日 · We report the isolation of a novel mammalian opsin-like gene, Opn5, the first member of a new opsin family. We have determined its gene structure, chromosomal localisation and tissue expression pattern in mice and humans.

2019年4月1日 · Here, we show that opsin 5 (OPN5; also known as neuropsin)-dependent retinal light responses regulate vascular development in the postnatal eye. In Opn5 -null mice, hyaloid vessels regress...