2024年12月25日 · ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1) is a Protein Coding gene. Diseases associated with ORAI1 include Immunodeficiency 9 and Myopathy, …

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. [5] [6] [7] Orai channels play an important role in the …

2006年8月20日 · We and others recently identified Drosophila Orai and human Orai1 (also called TMEM142A) as critical components of store-operated Ca2+ entry downstream of STIM6,7,8.

2025年2月8日 · ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. ORAI1 …

2020年5月15日 · We reveal that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their enhanced basal …

STIM1 couples with Orai1 at the junctions by protein interaction and induces opening of CRAC channels (Phase II, store-operated Ca 2+ entry). Opening of Orai1 raises the intracellular Ca …

Orai1, a pivotal actor of SOCE, was first identified by three independent interference RNA screens in Drosophila S2 cells that related a few Drosophila genes to SOCE, including olf186-F, …

2025年1月5日 · Title: Orai1 and Orai3 act through distinct signalling axes to promote stemness and tumorigenicity of breast cancer stem cells. Remodeling Ca[2+] dynamics by targeting a …

2025年2月8日 · Clinical resource with information about ORAI1, Combined immunodeficiency due to ORAI1 deficiency, Myopathy, tubular aggregate, 2, and available tests. There are links to …

ORAI 钙释放激活钙调节因子 1： 由该基因编码的蛋白质是一种膜钙通道亚基，当钙储备耗尽时，它会被钙传感器 STIM1 激活。这种类型的通道是钙流入 T 细胞的主要途径。该基因的缺陷 …