2014年3月20日 · In one model of mouse sleep-wake behavior by Diniz Behn et al., Orx was modeled as a state-dependent modulation of the inhibition of the VLPO by wake-active neuronal populations using a saturating mathematical form that mimics Orx activation on a timescale of minutes or longer.

腹外侧视前区（vlpo）是位于下丘脑前部的一个小神经元群。 [1] [2] 腹外侧视前区是控制人們唤醒与睡眠的神经系统。 [1] [2] 在非快速动眼睡眠期间，腹外侧视前核會释放抑制性神经递质。 [3]

2014年3月20日 · During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling narcolepsy, including frequent transitions between states, reduced waking arousal levels, and a normal daily amount of total ...

2018年7月23日 · 下丘脑腹外侧视前核（VLPO）在持续睡眠（入睡-保持睡眠）中起关键作用，而下丘脑的侧后部位神经元对保持清醒有用，这些神经元包括LHA脑区的食欲素神经元和TMN脑区的组胺能神经。 睡眠是一个自主过程，并非总是在我们直接、自愿的控制之下。 醒着或睡着，我们通常归属于两个生物调节基本过程：睡眠稳定（sleep homeostasis），即睡眠压力（sleep pressure）；另一个过程被称为昼夜节律（circadian rhythm），更广泛的说法也叫生物 …

Twenty-five years ago, Saper and colleagues uncovered a small collection of sleep-active neurons in the ventrolateral preoptic nucleus (VLPO) of the preoptic hypothalamus, and since this seminal discovery the VLPO has been intensively investigated by …

We demonstrated here that circadian clocks regulate the rhythmicity and magnitude of the vulnerability of DA neurons to oxidative stress in male Drosophila. Circadian pacemaker neurons are...

2014年3月20日 · During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling narcolepsy, including frequent transitions between states, reduced waking arousal levels, and a normal daily amount of total ...

incorporated the excitation of Orx on wake-active monoamin-ergic neurons (MA) and the inhibition of Orx on sleep-active ventrolateral preoptic neurons (VLPO). By utilizing this sleep model, we were able to replicate normal sleep with a 24-h circa-dian rhythm through circadian drive and homeostatic processes.

2020年6月10日 · 本文探讨了睡眠周期的数学模型，包括生物学层面的视交叉上核（scn）、食欲肽（orx）、睡眠促进核（vlpo）等相互作用。 通过Morris–Lecar和Hodgkin–Huxley模型，分析了睡眠与清醒状态的转换，以及REM和NREM睡眠阶段的交替。

During sleep, both Orx and MA are inhibited by the VLPO, and the subsequent reduction in Orx input to the MA indirectly stabilizes sustained sleep episodes. Simulating a loss of Orx, the model produces dynamics resembling