2024年12月25日 · OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include Amyloidosis, Primary Localized Cutaneous, 1 and Primary Cutaneous Amyloidosis. Among its related pathways are …

Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR), is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. [5] [6] OSMR is a member of the type I cytokine receptor family.

抑瘤素M（Oncostatin-M，OSM）属于IL-6家族成员中的多效性细胞因子，在1986年首次从U937组织性淋巴瘤细胞中释放并分离出来，因其可抑制黑色素瘤细胞的增殖能力而得名。 OSM基因位于22q12染色体上，由3个外显子和2个内含子组成，位置邻近于LIF。 OSM蛋白全长含有239至263个氨基酸，折叠成一个与其他IL-6家族相似的四螺旋束长链蛋白（图1） [3]。 人源OSM多肽含252个氨基酸残基，N-末端是由25个氨基酸残基构成的信号肽，C-末端由32个氨基酸残基构成。

The OSMR gene provides instructions for making a protein called oncostatin M receptor beta subunit (OSMRβ). This protein is one piece (subunit) of both the oncostatin M (OSM) receptor type II and the interleukin-31 (IL-31) receptor.

2025年1月4日 · This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.

The current study suggested that the OSMR gene is highly expressed in human chronic autoimmune urticaria (CAU) skin tissues, and cause the up-regulation of the JAK/STAT3 signaling pathway-related genes. OSMR gene silencing in mice inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of CAU.

2016年9月14日 · The OSMR gene provides instructions for making a protein called oncostatin M receptor beta subunit (OSMRβ). This protein is one piece (subunit) of both the oncostatin M (OSM) receptor type II and the interleukin-31 (IL-31) receptor. These receptors are embedded in the cell membrane of many types of cells throughout the body.

2024年9月12日 · Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines and has been found to have anti-inflammatory and pro-inflammatory properties in various...

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.

osmr的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为这个基因编码Ⅰ型细胞因子受体家族的类型的成员。 白细胞介素6信号转导编码蛋白杂二成二制瘤素M受体和白细胞介素31受体A型，形成白介素31受体，从而转导抑瘤素M和白细胞介素 ...