OTX2 Signals from the Choroid Plexus to Regulate Adult …
2019年5月7日 · We show that OTX2 activity modifies extracellular matrix components and signaling molecules produced by supporting astrocytes. Thus, we reveal a multilevel and non …
The homeobox gene Otx2 in development and disease
2013年6月1日 · The Otx2 homeobox gene is one of the most important genes for forebrain induction and head formation in vertebrates. In mouse embryo, Otx2 is already transcribed …
Orthodenticle homeobox 2 is transported to lysosomes by
2023年2月27日 · Here, we discover an unconventional nuclear export of the TF, orthodenticle homeobox 2 (OTX2), in nuclear budding vesicles, which transport OTX2 to the lysosome. We …
OTX2 Gene - GeneCards | OTX2 Protein | OTX2 Antibody
2024年12月25日 · OTX2 (Orthodenticle Homeobox 2) is a Protein Coding gene. Diseases associated with OTX2 include Microphthalmia, Syndromic 5 and Pituitary Hormone Deficiency, …
Non-cell-autonomous OTX2 transcription factor regulates
2021年5月7日 · Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2 +/AA and scFvOtx2 tg/0 mouse models for decreasing …
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma ... - Nature
2020年7月20日 · OTX2 is a potent oncogene that promotes tumor growth in Group 3 medulloblastoma. However, the mechanisms by which OTX2 represses neural differentiation …
Transcription Factor Otx2 - an overview | ScienceDirect Topics
Transcription Factor Otx2 is a key regulatory protein involved in the development of the pituitary gland, playing a role in cell type determination and differentiation. You might find these …
<br>OTX2 同源蛋白在成人脉络丛中的功能 ... - X-MOL
通过对组成型和条件敲低成年小鼠模型的 RNA 测序分析，我们揭示了 OTX2 在成年脉络丛功能中的假定功能作用，包括细胞信号传导和粘附，并表明 OTX2 调节分泌到脑脊液中的因子的表 …
otx2 在成人中脑-间脑多巴胺能神经元中的作用。 - X-MOL
2010年11月18日 · Otx2 表达仅限于 VTA 神经元的相关部分，在 SNpc 中不存在。 特别是，Otx2 普遍被排除在背外侧 VTA 的神经元之外，后者表达 Girk2 和高水平的多巴胺转运蛋白 (Dat)。
Otx2 and Oct4 Drive Early Enhancer Activation during Embryonic …
2014年6月26日 · The transcription factor Otx2 plays an important role in neural development and in the exit of embryonic stem cells from the pluripotent ground state. In this study, Yang et al. …