Impaired bone formation in ovariectomized mice reduces implant …
2017年9月14日 · Specifically, 12 week-old C57BL/6J mice underwent OVX/SHM surgery; 9 weeks after we inserted special metal-ceramics implants into the 6 th caudal vertebra and we …
Mechanical competence of ovariectomy-induced compromised …
2015年6月1日 · OVX caused a marked deterioration of the trabecular and cortical bone micro-structure, manifested as a considerable decrease in Ct.Th (−9%), BV (−52.6%), BV/TV …
PTH (1–34) treatment and/or mechanical loading have different ...
2020年6月1日 · This finding in Ct.Th is contrary to the constant linear increase observed in OVX rats 19, and in 19-months-old intact mice where PTH exacerbated age-related thinning of the …
去卵巢小鼠股骨微结构的动态变化研究 - tmmu.edu.cn
本研究以C57小鼠为实验动物，通过双侧卵巢摘除术诱导骨质疏松模型，模拟绝经后不同时期，应用micro-CT扫描和骨组织切片染色技术，观察术后不同时间点的骨量和骨组织形态学变化，旨 …
The longitudinal effects of ovariectomy on the morphometric ...
2019年10月1日 · A significant increase in Ct.Th was observed at week 16 in BL6-CTRL, but not until week 20 in BL6-OVX. In both BaC-CTRL and BaC-OVX, Ct.Th was significantly higher …
JCI - Ovariectomy induces bone loss via microbial-dependent …
Here, we show that ovariectomy (ovx) expanded intestinal Th17 cells and TNF + T cells, increased their S1P receptor 1–mediated (S1PR1-mediated) egress from the intestine, and …
【中科院1区12.4】微生物+代谢+转录组｜浙大附属邵逸夫医院姚 …
2025年1月2日 · 研究发现，肠道微生物群的耗竭会显著削弱运动对骨质疏松的保护作用，而 FMT能够有效传递运动小鼠的肠道微生物特征，从而改善骨质流失，为通过调节肠道微生物群 …
小鼠卵巢摘除模型OVX（骨质疏松）构建细节 - 知乎
小鼠卵巢摘除（ovariectomy，简称ovx）是一个较成熟的动物模型，通过双侧 卵巢摘除术 可以成功建立模拟雌激素缺乏而导致的骨质疏松动物模型。 卵巢所在位置 图源网络
The influence of therapeutic radiation on the patterns of bone ...
Ct.Th increased in the OVX groups following irradiation. I+R mice exhibited diminished osteoblast surface, osteoclast number, and mineral apposition. Our murine model showed the systemic …
Impaired bone healing pattern in mice with ovariectomy-induced ...
2011年6月1日 · Micro-CT reconstruction and histological examination consistently demonstrated less new bone formation in both defect region (day 10 and day 14) and intra-medulla region …
The unique role of bone marrow adipose tissue in ovariectomy …
2023年9月8日 · Micro-CT, osmium tetroxide staining, and histological analyses were performed to examine the changes in bone microstructure, BMAT and white adipose tissue (WAT) in OVX …
The Magnitude and Rate of Bone Loss in Ovariectomized Mice …
2008年6月26日 · The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo …
Corylifol A protects against ovariectomized-induced bone loss and ...
2023年2月20日 · In vivo, CA effectively prevented trabecular bone loss and reduced osteoclasts' number on the bone surface in OVX mice, as demonstrated in micro-CT, osteometry, and …
Cortical and trabecular morphology is altered in the limb ... - Nature
2017年9月5日 · In this study, we used longitudinal micro-CT scans in ovariectomized and sham-operated Longshanks and random-bred control mice to test the overall hypothesis that …
The Influence of Therapeutic Radiation on the Patterns of Bone ...
2013年1月12日 · Ct.Th increased in the OVX groups following irradiation. I+R mice exhibited diminished osteoblast surface, osteoclast number, and mineral apposition. Our murine model …
The effects of simvastatin on the bone microstructure and …
2024年9月18日 · This study aimed to investigate the effect of simvastatin on the bone microstructure and bone mechanical properties in ovariectomized (OVX) mice. 24 female …
Early effects of ovariectomy on bone microstructure, bone …
2022年4月2日 · Vertebral bones and femurs were dissected completely for micro-Computed Tomography (micro-CT) scanning, biological modulus detection and histomorphological …
骨微结构参数可以在微型骨CT减轻兔骨质疏松模型中的骨密度之前 …
这项研究旨在确定X射线显微断层扫描（micro-CT）在预测兔骨质疏松症（OP）模型中催产素（OT）治疗反应中的功效。 65只兔随机分为三组：对照组，卵巢切除术（OVX）载体和OVX …
Micro-CT in Osteoporosis Research - SpringerLink
2019年7月26日 · Micro-CT is a widespread tool used for observing the changes in the microarchitecture of the bone tissue; thus the pathology of osteoporosis and the effects of …
Bone microarchitectural parameters can detect oxytocin induced …
2019年11月23日 · Bilateral ovariectomy (OVX) rats are generally used as a classical OPanimal model for postmenopausal OP research. However, the rat skeletal system is different from …