2024年3月21日 · Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and...

2024年10月28日 · This part is to establish an ovariectomy (OVX) mice model and explore the subsequently changes in mice. Twenty-four female mice were randomly divided into 3 groups: sham group, 3-day post-OVX group and 7-day post-OVX group (n = 8 per group). The mice in the sham group received the same surgery except for OVX.

Ovariectomized (OVX) animal is a typical experimental model for investigation of postmenopausal osteoporosis due to estrogen deficiency in women. Recently, both OVX mouse and OVX rat are commonly used for the evaluation of bone tissues in the animal model.

Ovariectomy (OVX) leads to hyperphagia and weight gain in rats, which can be prevented by estradiol (E2) replacement; however, the role of endogenous E2 on feeding and energy homeostasis in female mice has not been well characterized.

2014年1月13日 · Adult ovariectomized (OVX) female mice and 22-month-old female mice received daily subcutaneous injections of 100 μg/kg or 300 μg/kg 17β-estradiol (E2) at the back of the neck for four weeks, and the expression levels of estrogen receptor (ER) α and β in the cerebral cortex were determined using real-time PCR and Western blotting analyses.

2024年10月1日 · In this study, we evaluated the protective effects of several probiotic strains against menopausal symptoms in female OVX mice. We first examined the estrogenic activity of probiotics using an in vivo uterotrophic assay. Then, we evaluated the long-term effects of selected probiotic strains on menopausal symptoms including metabolic disorders ...

2022年10月30日 · In particular, the cell-extrinsic response of female mSSC to ovariectomized environment reduces clonogenicity and skeletogenic differentiation, and could provide a mechanism of impaired OVX...

2015年6月15日 · In this study, we hypothesized that provision of 17β-estradiol (E2) to ovariectomized (OVX) high-fat (HF)-fed female hypertensive mice would reverse obesity-hypertension through an ACE2-dependent mechanism. Pilot studies defined dose-dependent effects of E2 in OVX female mice on serum E2 concentrations and uterine weights.

2024年3月17日 · When circulating levels of AKG, arginine, and carnosine, which showed the most significant changes in OVX mice blood, were measured in postmenopausal women, higher plasma AKG levels were associated with lower bone mass, weak grip strength, poor physical performance, and increased frailty risk.

2018年7月18日 · We investigated the consequences of ovariectomy (OVX) and E 2 replacement in female marmoset monkeys on major metabolic and morphometric endpoints. Sexual behavior and uterine diameters were...