Flow cytometry and fluorescence microscopy analyses showed that cellular uptake of fluorescence (Dil)-labeled oxLDL was significantly augmented with LPS stimulation. The …

2018年3月8日 · Aside from a TLR4 antagonistic role, oxPAPC binds directly to caspase-4 and caspase-11, competes with LPS binding, and consequently inhibits LPS-induced pyroptosis, IL …

We found that diverse NLRP3 inflammasome activators rapidly stimulated uniporter-mediated calcium uptake to open mitochondrial permeability transition pores (mPTP) and trigger VDAC …

2023年6月25日 · 血管内皮细胞表面高表达凝集素样 氧化低密度脂蛋白 (LDL)受体-1 (LOX-1)，能够结合并将氧化低密度脂蛋白 (oxLDL)转移到动脉粥样硬化中被巨噬细胞浸润的血管内膜。 巨 …

2023年9月1日 · In the present study, polymyxin (PMB) covalently conjugated to PEGylated liposomes (PLPs) were formulated to adsorb LPS through specific interactions between PMB …

2014年10月28日 · Flow cytometry and fluorescence microscopy analyses showed that cellular uptake of fluorescence (Dil)-labeled oxLDL was significantly augmented with LPS stimulation. …

2019年4月3日 · ox-LDL会通过一些信号通路诱发较强的细胞毒性作用, 最终可导致巨噬细胞、平滑肌细胞、内皮细胞的退化凋亡 。本研究发现相同浓度ox-LDL诱导后, THP-1凋亡比率增加近2 …

Here, we investigated how oxLDL modulates lipopolysaccharide (LPS)-induced inflammatory mediators in RAW 264.7 murine macrophages. Our results showed that oxLDL dramatically …

2019年4月10日 · Using confluent cultures of Caco-2 cells, a well-known in vitro model of small intestinal enterocytes, we demonstrate a protective role of OX-A against LPS-mediated …

Oxidised lipoprotein (a) [oxLp (a)] is considered as a more potent arteriosclerotic factor than native Lp (a). However, the molecular mechanisms underlying this potency remain unclear. …