Conversion of compound 4 to oxazolidi-none 6 was accomplished by use of n-BuLi and (S)-3, 4-epoxybutenyl propionate (5). The alcohol 6 was reacted with methanesulfonyl chloride, followed by a treatment of sodium azide to yield compound 7.
Syntheses and antibacterial activity studies of new oxazolidinones …
2010年2月1日 · Using the optimized NDA reaction conditions, a series of new oxazolidinones 23a – 25b with bicyclic oxazines at the C-5 side chain were synthesized. Among them, …
Catalytic transformation of carbon dioxide into seven …
2 天之前 · In order to take advantage of the free –NH group in bicyclic oxazolidinone 13a (Fig. 5b), it was treated with an acyl chloride after activating it by n -BuLi delivering compound 21 (61%), which ...
- Oxazolidinone with n-BuLi 的研究
Organic Syntheses Procedure
N-Aryl-5- R -hydroxymethyl-2-oxazolidinones, represented by 3, are important intermediates for the synthesis of oxazolidinone antibacterial agents. The procedure previously reported 3 and illustrated in Scheme 1 applied the …
The most significant oxazolidinone prepared to date is PNU-I00766 (linezolid) (Brickner, Hutchin son, Barbachyn et aI., 1996). This morpholine derivative is readily prepared in seven steps …
Oxazolidinones as a new class of synthetic an-timicrobial agents are active against numerous multidrug-resistant Gram-positive organisms [1]. Linezolid 1a and Eperezolid 1b (Fig. 1), which …
Syntheses and biological evaluation of new cephalosporin …
2010年8月1日 · Then, as reported, 7a compound 6 was sequentially treated with n BuLi and R -glycidyl butyrate at −78 °C to form the key oxazolidinone 7 in 71% yield with defined …
Syntheses and biological evaluation of new - RSC …
Palladium catalyzed hydrogenation of compound 5 followed by reaction with CbzCl gave protected aniline 6. Then, as reported, 7a compound 6 was sequentially treated with n BuLi and R -glycidyl butyrate at −78 °C to form the …
A Novel Synthesis of the Oxazolidinone Antithrombotic Agent …
2014年9月18日 · Most reported methods for the synthesis of 1 involve the construction of the 5-aminomethyl-3-aryl oxazolidinone 2 as a key step [5, 6, 7, 8, 9, 10]. A common strategy for the …
Oxazolidinones as chiral auxiliaries in asymmetric aldol reactions ...
2013年10月15日 · In the first step, Evans aldol reaction of boron enolate derived from oxazolidinone 21 reacted with chiral aldehyde 89 to form aldol adduct 256 in 87% yield and …