2024年11月15日 · • Aldoxime dehydratases (Oxds) are promising for cyanide-free routes to nitriles. • A comprehensive overview of wet-lab explored Oxds is provided. • Recent trends include combining Oxds with other enzymes or chemical catalysts. Nitriles are a …

2024年11月15日 · KEY POINTS: • Aldoxime dehydratases (Oxds) are promising for cyanide-free routes to nitriles • A comprehensive overview of wet-lab explored Oxds is provided • Recent trends include combining Oxds with other enzymes or chemical catalysts.

2021年7月12日 · Aldoxime dehydratases (Oxds; E.C. 4.99) are special heme containing lyases involved in the “aldoxime–nitrile-pathway” of microbes (Fig. 1). These enzymes catalyse...

2022年12月15日 · Pro-oxidant enzymes include oxidase (OXD), peroxidase (POD), and glucose oxidase (GOx) among others, which can catalyze ROS production from H 2 O 2, O 2, etc., as well as promote substrate oxidation. Both pro-oxidant and anti-oxidant enzymes are widely used in biosensing and antibacterial pathways [8], [9], [10], [11], [12].

2024年7月15日 · The OXD-like nanomaterials catalyze oxidation of organic substrate, such as 3,3′,5,5′-Tetramethylbenzidine (TMB), glucose, o-phenylenediamine (OPD), and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) by oxygen molecules as the substrate, depending on the types of hydrogen donors [7].

Aldoxime dehydratase (Oxd) is a heme enzyme that catalyzes aldoxime dehydration to the corresponding nitriles. Unlike many other heme enzymes, Oxd has a unique feature that the substrate binds directly to the heme. Therefore, it is thought that structural differences around the bound heme directly r …

2020年12月1日 · Fan et al. designed an N-doped porous carbon nanospheres (N-PCNSs) system contain four enzyme-like activities: SOD, CAT, POD, and OXD, for oxygen oxidation and reduction under physiological conditions.

2018年4月12日 · We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive...

Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the synthesis of a range of nitrile products.

2024年9月7日 · 该团队通过简单的主客体原位组装及高温热解策略构建了具有多种催化活性位点的钼铜双原子纳米酶（MoCu DAzyme），并将其用于类酶催化/光热协同抗肿瘤治疗 (图1)。