2024年12月25日 · OXSM (3-Oxoacyl-ACP Synthase, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein degradation. Gene Ontology (GO) annotations related to this gene include transferase activity and 3-oxoacyl- [acyl-carrier-protein] synthase activity. An important paralog of this gene is FASN.

Ubiquitous expression in testis (RPKM 3.3), thyroid (RPKM 1.6) and 25 other tissues. 该基因编码一种β-酮脂酰合成酶。 所编码的酶是线粒体中脂肪酸链延长所必需的。 已经描述了可变剪接的转录变体。 [RefSeq 提供，2009 年 2 月] This gene encodes a beta-ketoacyl synthetase. The encoded Enzyme is required for elongation of fatty acid chains in the mitochondria.

Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). Duan Y, et al. J Ovarian Res, 2023 Apr 22. PMID 37087461, Free PMC Article

2025年2月8日 · Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Located in mitochondrion.

2019年4月23日 · OXSM (also named as β-ketoacyl synthase in mitochondria) is the second enzyme in the synthetic pathway of LA. The activity of OXSM is required for elongation of fatty acid chains in the production of LA. The enzyme is encoded by the nuclear DNA. In human and mouse, the enzyme gene is expressed in all types of tissues.

预测在脂肪酸代谢过程的上游或内部发挥作用。位于线粒体中。在背根神经节；肺；神经系统；周围神经系统；和呼吸系统中有表达。与人类的oxsm（线粒体3-氧代酰基acp合成酶）正链同源。[由基因组资源联盟，2022年4月提供]

预测能够激活3-氧代酰基-[酰基载体蛋白]合成酶活性。预测参与酰基coa代谢过程；中链脂肪酸生物合成过程；短链脂肪酸生物合成过程。预测位于细胞质和线粒体中。与人类oxsm(线粒体3-氧代酰基acp合成酶)正同源。[由基因组资源联盟，2022年4月提供]

Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process; medium-chain fatty acid biosynthetic process; and short-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion.

Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in dorsal root ganglion; lung; nervous system; peripheral nervous system; and respiratory system. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

oxsm的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码一种β-酮脂合成。 所编码的酶需要的线粒体脂肪酸链伸长。