3 天之前 · Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb detects IKKα only when phosphorylated at Ser176/180 and IKKβ only when phosphorylated at Ser177/181. The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST.

IKK是一种常见的 转录因子 激活蛋白 [1]，可以被位于 细胞质膜 的 TNF -TNFR复合体、 IL -ILR复合体、活化的 Toll样受体 、 病毒感染 和胞外电离辐射激活。 常见的 炎症因子 (包括IL-α和TNF-α等)都可以参与激活IKK。 NF-κB 由两类 亚基 形成的 异源二聚体，一类亚基包括p65，另一类亚基为p50。 NF-κB未被激活时和 IκB -α形成一个复合物，分布在细胞浆中。 在炎症因子、 生长因子 或 趋化因子 等可以激活IKK的情况下，IκBkinase (IKK)复合物会被NF-κB-inducingkinase磷酸 …

2004年5月1日 · Inflammatory stimulation of endothelial cells by tumor necrosis factor α (TNF-α) involves activation of nuclear factor κB (NF-κB) and p38 mitogen-activated protein (MAP) kinase signaling pathways. A reliable analysis of the gene expression program elicited by TNF-α and its assignment to distinct signaling pathways is not available.

IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKK alpha and IKK beta). IKK alpha and IKK beta interact with each other and both are essential for NFkB activation. IKK alpha specifically phosphorylates IkBa. …

p38 MAPK（α、β、γ 和 δ）是 MAPK 家族的成员，各种环境应激和炎症细胞因子均可将其激活。 对于其他 MAPK 级联，膜近端组分是一个 MAPKKK，其为典型的 MEKK 或混合性谱系激酶 (MLK)。 MAPKKK 磷酸化并激活 MKK3/6，后者即是 p38 MAPK 激酶。 MKK3/6 也可在凋亡因素的刺激下直接由 ASK1 激活。 p38 MAPK 参与调节 HSP27、MAPKAPK-2 (MK2)、MAPKAPK-3 (MK3) 和其他几种转录因子，包括 ATF-2、Stat1、Max/Myc 复合体、MEF-2 和 Elk-1，而 …

Stress-activated MAP kinases (MAPKs), comprised of JNK and p38, play prominent roles in the innate and adaptive immune systems. Activation of MAPKs is mediated by a three-tiered kinase module comprised of MAPK kinase kinases (MAP3Ks), MAPK kinases (MAP2Ks) and MAPKs through sequential protein phosphorylation.

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

抑制性 kappa B 激酶 beta (IKKβ)，称为 IKK2，是一种关键的调节激酶，通过其 Ser177 和 Ser181 磷酸化来激活 NF-κB，从而促进 kappa B 抑制剂 (IκB) 的磷酸化，触发其泛素化和降解以激活核因子 kappa-B (NF-κB) 级联。 化学抑制IKKβ或其基因敲除已成为阻断NF-κB介导的肿瘤细胞增殖和迁移以及炎症反应的有效方法。 在这篇综述中，我们总结了IKKβ的结构特征和转导机制，以及从自然资源（如倍半萜类、二萜类、三萜类、黄酮类和生物碱类）和化学合成类（如嘧啶类、吡啶类 …

In this review, we discuss signaling pathways involved in COPD pathogenesis and review clinical studies of p38 MAPK inhibitors, TNFα inhibitors, and IKK2 inhibitors as potential COPD therapies. Keywords: airways disease, inflammation, irreversible airway obstruction, airway remodeling.

在炎症因子、生长因子或趋化因子等可以激活NF-κB的刺激存在的情况下，IκB kinase(IKK)复合物会被NF-κB- inducing kinase磷酸化激活，导致IκB-α会在Ser32和Ser36位点被磷酸化，随后被泛素-蛋白酶体途径降解。