Phospho-eIF2α (Ser51) Antibody | Cell Signaling Technology
Polyclonal Antibody for studying EIF2S1/eIF2-alpha (Ser52) phosphate. Validated for WB, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-eIF2α (Ser51) Antibody (CST #9721) is ready to ship.
真核起始因子2 - 维基百科，自由的百科全书
eIF2 （eukaryotic Initiation Factor 2，真核起始因子2）是一个重要的 真核起始因子，它的作用是在 真核翻译 起始过程中介导起始 tRNA （Met-tRNA i）与 核糖体 结合。 它是一个异源三聚体，由α、β、γ三个 亚基 组成。 eIF2也是第一个被发现的其蛋白 磷酸化 作用能够调控真核翻译的起始因子。 eIF2在真核翻译起始过程中扮演着关键角色。 它与 GTP 以及起始tRNA形成三聚体复合物（TC），在 eIF3 和 eIF5 的作用下，TC结合到40S核糖体亚基上共同形成43S前起始复合物 …
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in …
2020年6月8日 · EIF2AK2, commonly known as protein kinase R (PKR), is activated by viruses and alcohol 11, 12. EIF2AK3, commonly known as protein kinase R-like endoplasmic reticulum (ER) kinase (PERK),...
Phospho-eIF2α (Ser51) (D9G8) XP - Cell Signaling Technology …
Monoclonal Antibody for studying EIF2S1/eIF2-alpha (Ser52) phosphate. Validated for IHC, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit Monoclonal Antibody (CST #3398) is ready to ship.
eIF2 调控 | Cell Signaling Technology
eIF2 起始复合体整合了各种各样应激相关的信号来调控全局和特异性 mRNA 翻译。 在适宜的条件下，eIF2 会结合 GTP 和 Met-tRNAi 形成三元复合体 (TC)，三元复合体随后结合 40S 核糖体亚基、eIF1、eIF1A、eIF5 和 eIF3，形成 43S 起始前复合体 (PIC)。
Phosphorylation of the translation initiation factor eIF2
2015年1月15日 · At the molecular level, we demonstrate that eIF2 α P acts through an ATF4-independent mechanism to control Akt activity via the regulation of mTORC1. Specifically, eIF2 α P downregulates...
Modulation of p-eIF2α cellular levels and stress granule assembly ...
2017年3月9日 · We found that pretreatment of cells with a natural disaccharide trehalose, a known autophagy enhancer, delays SG assembly and facilitates their premature post-stress disassembly. Mechanistically,...
碧云天生物技术-Phospho-eIF-2α (Ser51) Rabbit Polyclonal Antibody (p …
Phosphorylation of the eukaryotic initiation factor 2 (eIF2) α subunit is a well-documented mechanism to downregulate protein synthesis under a variety of stress conditions. eIF2 binds GTP and Met-tRNAi and transfers Met-tRNA to the 40S subunit to form the 43S preinitiation complex. eIF2 promotes a new round of translation initiation by ...
eIF2α信号通路相关研究进展 - 百度文库
目前发现了四种磷酸化eIF2α的丝氨酸琳氨酸蛋白激酶，分别是HRI，PERK，PKR及GCN2。 本文就该信号通路的研究进展进行总结分析。 eIF2α的磷酸化现象最早在兔网织红细胞中发现：血红素缺乏会激活一种eIF2α激酶导致eIF2α的磷酸化，从而控制细胞蛋白的合成。 这种被激活的激酶即血红素调节抑制因子HRI又叫HCI或HCR （Chen et al. 1991）。 接着又发现了能被dsRNA激活的eIF2a激酶PKR从酵母中也得到了一种eIF2a激酶GCN2 在氨基酸饥饿时被激活。 后来又发现 …
The integrated stress response in neurodegenerative diseases
2025年2月19日 · Once activated, PERK then phosphorylates eIF2α (p-eIF2α), preventing the translation of mRNA and reducing protein synthesis, which allows the ER to either refold or dispose of the ... eIF2 participates in mRNA translation and recognition of the initiation codon AUG . eIF2 is a 126 kDa heterotrimer protein comprised of α, β ...