Phospho-SMAD2 (Ser465/467) (138D4) Rabbit mAb detects endogenous levels of SMAD2 only when dually phosphorylated at serines 465 and 467, and may detect SMAD3 phosphorylated at the equivalent sites. This antibody does not cross-react with other SMAD-related proteins.

Monoclonal Antibody for studying Smad2 (Ser465/Ser467) phosphate/Smad3 (Ser423/Ser425) phosphate. Validated for WB. Available in 2 sizes.

R-Smad C末端SXS基序（X指代M或V）中的丝氨酸(S)能直接被I型受体磷酸化而导致R-Smad活化，其中Smad2/3被TGF-β/activin/nodal亚家族的I型受体ALK4/5/7磷酸化，而Smad1/5/8则主要被BMP/GDF/AMH亚家族的ALK2/3/6和ALK1磷酸化。

激活的 SMAD 复合物转移到细胞核中，与靶基因启动子区域的位点特异性识别序列结合，直接调节它们正向和负向的转录，包括 DNA 结合辅助因子，如 p300、CBP。 图 2. 哺乳动物 TGFβ/SMAD 通路中的核心信号 [6] 细胞中 TGF-β 信号传导的多样性不仅取决于各种配体、受体、SMAD 介质或 SMAD 相互作用蛋白，还取决于 TGF-β 激活其他信号通路的能力。 在非经典途径中，TGFβ 受体复合物通过其他因子传递信号，如 TRAF4 或 TRAF6、TAK1、p38 MAPK、RHO、PI3K …

Phospho-Smad2 (Ser465/467)+Smad3 (Ser423/425) Rabbit Polyclonal Antibody -20ºC保存，Western一抗稀释液-20ºC或4ºC保存，一年有效。 Western一抗稀释液优先推荐4ºC保存，长期不使用可以考虑-20ºC保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。

Invitrogen Anti-Phospho-SMAD2 (Ser465, Ser467) Polyclonal, Catalog # 44-244G. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Paraffin) (IHC (P)) and ChIP Assay (ChIP) applications. This antibody reacts with Human, Mouse samples. Supplied as 100 µL purified antibody.

Phospho-Smad2 (Ser465/467) (E8F3R) Rabbit mAb recognizes endogenous levels of Smad2 protein when phosphorylated at Ser465 and Ser467. Human, Mouse, Rat. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser465/467 of human Smad2 protein.

Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity).

该交互通路海报介绍了经典的 TGF-β 信号传导，涉及配体（TGF-β1、INHB、BMP4）、受体（TGFBR1/2）、受体活化型 SMAD（SMAD1/2/3/5/9）和普通 SMAD（SMAD4）。 通过TGF-β通路海报了解如何通过抑制性SMAD、转录因子和辅助因子调控TGF-β信号传导；同时了解经典TGF-β通路中关键蛋白之间的复杂相互作用；助您选择适合您研究的产品。 通路海报可免费下载。

SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as …