TBR1 directly represses Fezf2 to control the laminar origin and
2011年2月1日 · Here we show that the transcription factor TBR1 directly binds the Fezf2 locus and represses its activity in L6 corticothalamic projection neurons to restrict the origin of the …
Shared and Distinct Functional Effects of Patient-Specific Tbr1 ...
2022年9月14日 · We first measured TBR1 protein levels in P0 cortex from Tbr1 KO mice (heterozygotes denoted as Tbr1 +/–, homozygotes denoted as Tbr1 –/–) and the CRISPR …
Tbr1 Regulates Differentiation of the Preplate and Layer 6 - Cell …
2000年9月21日 · Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1 -deficient mice, these early-born neurons had molecular …
Tbr1 regulates regional and laminar identity of postmitotic ... - PNAS
Tbr1 regulates laminar identity in part by downstream activation or maintenance of Sox5, an important transcription factor controlling neuronal migration and corticofugal axon projections. …
Tbr1 instructs laminar patterning of retinal ganglion cell dendrites
2018年4月9日 · We show that the transcription factor Tbr1 is expressed by four mouse RGC types with dendrites in the outer IPL and is required for their laminar specification. Loss of …
Tbr1 and Fezf2 Regulate Alternate Corticofugal Neuronal Identities ...
2011年1月1日 · We present evidence for central transcriptional mechanisms that regulate fate specification of corticothalamic (layer 6) and subcerebral (layer 5) projection neurons. We …
Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity
2018年11月21日 · TBR1 directly regulates transcriptional circuits in heterozygous mutant mice that specify layer 6 identity and synapse number. As TBR1 is an ASD risk gene, our results …
Shared and Distinct Functional Effects of Patient-Specific Tbr1 ...
2022年9月14日 · Tbr1 A136PfsX80 is a loss-of-function mutation, while K228E mutation causes TBR1 upregulation. A, B, Western blots for TBR1 in P0 cortical lysates from Tbr1 mutant …
Brain-specific transcriptional regulator T-brain-1 controls brain ...
T-brain-1 (TBR1) is a brain-specific T-box transcription factor. In 1995, Tbr1 was first identified from a subtractive hybridization that compared mouse embryonic and adult telencephalons. …
Intermediate Progenitor Cohorts Differentially Generate Cortical …
2016年6月28日 · Our findings indicate that upper-layer genesis depends on IPs from many stages of corticogenesis and that Tbr2 regulates the tempo of laminar fate implementation for all …