2013年2月1日 · Using a rational approach, we designed a novel and selective peptide inhibitor, P110, of excessive mitochondrial fission. P110 inhibits Drp1 enzyme activity and blocks …

2023年7月19日 · Our study demonstrates that small molecule inhibitors of protein-protein interactions can be generated for Drp1 and that the P110 -binding site is an unrecognized …

2025年1月17日 · 通过P110抑制Drp1/Fis1相互作用，有效降低了脓毒症小鼠线粒体细胞色素C的释放水平，并减轻了神经炎症，表现为肿瘤坏死因子TNFα、白介素ILI-β和白介素IL-6等炎症标 …

2025年3月5日 · Here, we investigate the therapeutic potential of P110, a selective inhibitor of Drp1-mediated mitochondrial fission, in experimental models of DN. We demonstrate that …

2016年9月13日 · This study demonstrates that inhibition of Drp1 hyper-activation by a Drp1 peptide inhibitor P110 mitigates MPTP-induced loss of dopaminergic neurons, inhibits MPTP …

P110 heptapeptide, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological …

P110是一种 Drp1-Fis1 相互作用的肽抑制剂，可减少多种神经退行性变、缺血和脓毒症模型的病理，而不会阻断 Drp1 的生理功能。 由于肽具有药代动力学限制，我们开始寻找能够模仿P110 …

2017年6月1日 · Inhibition of Drp1 hyper-activation by the selective inhibitor P110 abolishes Drp1 translocation to the mitochondria, reduces mitochondrial fragmentation and stems necrosis in …

Here, we investigate the therapeutic potential of P110, a selective inhibitor of Drp1-mediated mitochondrial fission, in experimental models of DN. We demonstrate that P110 effectively …

2024年3月4日 · The use of the Drp1 inhibitor P110 significantly improved kidney function and structural damage. P110 reduced Drp1 mitochondrial translocation, disrupted the interaction …