For instance, molecular and functional profiling of anti-viral memory CD8 + T cells was performed using P14 TCR Tg mice. This led to the discovery of many important memory T cell differentiation-associated molecules such as IL-7 receptor (CD127), KLRG-1, and IL-15 [43,44,45,46].

2023年5月1日 · P14 TCR-transgenic B6 mice, which carry T cell receptors specific for the LCMV glycoprotein 33-41 peptide residues (GP 33-41) in the context of H-2D b, and...

2023年2月1日 · By generating P14 TRex mice with the same specificity as the widely used LCMV-P14 TCR transgenic mouse, we demonstrate increased avidity of Trac -targeted TCRs over transgenic TCRs, while...

We examined T cell development and T cell repertoire in transgenic mice expressing a single T cell receptor (TCR) alpha chain derived from the H-2Db-lymphocytic choriomeningitis virus (LCMV)-specific cytolytic T lymphocyte (CTL) clone P14. To generate these alpha P14 mice, mice transgenic for the P1 …

2020年9月8日 · P14 cells were adoptively transferred into mice 1 day prior high or low-dose LCMV clone 13 infection. Animals were sacrificed after 14 days. CD8 + P14 cells were stimulated with anti-CD3 and...

The Rag2 Knockout/Transgenic LCMV-P14 T Cell Receptor line is homozygous for a transgene that encodes a T cell receptor that is specific for a peptide (P14) from the lymphocytic choriomeningitis virus (LCMV) presented by the MHC class I molecule H2-Db.

(A) P14 mice expressing a transgenic Va2 + and Vb8 + TCR were crossed to twp mice. Single-positive CD8 + thymocytes expressing the transgenic TCR were quantified by flow cytometry.

P14 TCR-transgenic mice have been extensively used for analysing T cell responses to the index peptide, gp33, and a range of altered peptide ligands (APL), including antagonists and strong, weak and partial agonists previously shown to elicit a wide range of biological effects .

Bioz Stars score, Techniques, Protocol Conditions and more for P14 Mice, supplied by The Jackson Laboratory. Data for P14 Mice gathered from related PubMed articles.

P14 mice expressing a transgenic TCR specific for the lymphocytic choriomeningitis virus glycoprotein p33 epitope were used to study the induction of CTL effector activity by a variety of ligands. Surprisingly, p33 variants which are weaker agonists for the P14 TCR than the wild-type p33 peptide wer …