p14ARF (also called ARF tumor suppressor, ARF, p14 ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). [1] p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). [2]

2024年12月24日 · CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) is a Protein Coding gene. Diseases associated with CDKN2A include Melanoma, Cutaneous Malignant 2 and Melanoma-Pancreatic Cancer Syndrome.

P14 ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14 ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14 ARF functions can be …

P14ARF is involved in cell cycle regulation by binding to HDM2, which in turn inhibits p53 degradation and leads to cell cycle arrest. HDM2 not only targets p53 for degradation, but also leads to functional inactivation of pRb.

2024年11月11日 · p14 ARF reduces nucleolar NPM1 mobility and cell proliferation. NPM1 localizes p14 ARF in nucleoli to inhibit it from engaging other binding partners and activating anti-proliferative pathways...

CDKN2A gene mutations involved in cancer impair production of functional p16(INK4A) or, less commonly, p14(ARF), which can result in uncontrolled cell growth and tumor formation. Somatic CDKN2A gene mutations have been found in some people with brain tumors and in children with a blood cancer called acute lymphoblastic leukemia.

2006年11月21日 · CDKN2A locus on chromosome 9p21 encodes two tumour suppressor proteins pl6 INK4A, which is a regulator of the retinoblastoma (RB) protein, and p14 ARF, which is involved in the ARF–Mdm2–p53...

The CDKN2A gene encodes two different proteins with distinct functions: p16 and p14. The sequence codifying these two protein isoforms differs within the first exon (exon 1α and exon 1β for p16 and for p14, respectively) as a result of alternative splicing and a different reading frame ( Stone et al., 1995 ).

2020年7月20日 · P14 ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14 ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14 ARF functions can be played through interactions with several proteins.

1998年9月10日 · Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein p14 ARF (the mouse homologue is called p19 ARF), which binds to the MDM2-p53 complex and prevents p53...