p16 INK4A Antibody detects endogenous levels of p16 INK4A protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues within the carboxy-terminal region of human p16 INK4A. Antibodies are purified by protein A and peptide affinity chromatography.

p16 INK4A (D7C1M) Rabbit mAb recognizes endogenous levels of total p16 INK4A protein. This antibody does not cross-react with p15 INK4B. This antibody is not recommended for use in immunohistochemistry.

Monoclonal p16 antibody for studying endogenous levels of total p16 INK4A protein. Validated for IHC. Available in 2 sizes. Learn more here.

The tumor suppressor protein p16Ink4a (encoded from the CDKN2A locus) is often transcriptionally activated in cells undergoing senescence and is one of the main regulators of this program, and it is upregulated in multiple tissues during aging (PMID:17055429). p16-Ink4a is the principal member of the Ink4 family of CDK inhibitors. p16-Ink4a ...

p16ink4a (p16)是一种周期蛋白依赖的激酶抑制剂，通过抑制cdk4/6来阻断e2f转录因子的激活，负调控正常细胞的增殖。 ink4周期素依赖性激酶抑制剂家族成员包括 p16 ink4a、p15 ink4b、p18 ink4c 和 p19 ink4d。 cdkn2a/p16ink4a位于染色体9p21.3上，并丢失邻近的肿瘤抑制基因簇。

Cdkn2a (cyclin-dependent kinase inhibitor 2a) is a cell cycle regulating gene encoding alternate proteins, p16Ink4a and p19Arf, that arrest the G1 phase through CDK4/6 inhibition. As they are tumor suppressors, p16Ink4a and p19Arf can be targeted for treatment of various cancers, including melanoma, cervical, and esophageal cancers.

P16INK4a (p16) is a cyclin-dependent kinase inhibitor that blocks the activation of the E2F transcription factor by inhibiting CDK4/6, negatively regulating the proliferation of normal cells. Read our P16INK4a (p16) target tip to learn more about how to work with this protein

p16 inhibitor of CDK4, p16INK4a, is a 16 kDa tumor suppressor protein. It works as an inhibitor of the CDK4/CDK6-mediated cell cycle regulation of the G1/S phase transition. A decrease in p16 expression can lead to an upregulation of CDK4-mediated activation of retinoblastoma (Rb) protein accelerating cell proliferation. p16 expression has been ...

CDKN2A/p16INK4a Antibody is an unconjugated, approximately 16 kDa, rabbit-derived, anti-CDKN2A/p16INK4a monoclonal antibody. CDKN2A/p16INK4a Antibody can be used for: WB, IHC-P expriments in human background without labeling. HeLa cell lysate, HepG2 cell lysate, HEK-293 cell lysate, NIH:OVCAR-3 cell lysate, human ovary carcinoma tissue.