p16 - Wikipedia
p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing …
p16ink4a基因分子生物学研究进展 张毅彬 - 知乎
【摘要】 抑癌基因 p16ink4a在特异地抑制 CDK4及CDK6在控制细胞生长、 抑制肿瘤发生、 促进细胞衰老等方面发挥关键生物学作用, 该基因失活后造成了细胞周期调控失常,使得细胞异常增 …
Increased stability of the p16 mRNA with replicative senescence
Here, we report the presence of an instability determinant within the 3′-untranslated region (UTR) of the p16 messenger RNA in WI-38 human diploid fibroblasts. The p16 3′UTR was found to …
p16 a biomarker of aging and tolerance for cancer therapy
This review focuses on p16, a crucial biomarker of cell senescence and molecular aging, the methodology of p16 measurement in humans, and the utility of p16 expression in guiding …
p16 High senescence restricts cellular plasticity during ... - Nature
2023年8月31日 · Our results show that the presence of p16 High senescent cells limits cell plasticity, whereas their depletion can promote a totipotent-like state and histopathological …
Defined p16 High Senescent Cell Types Are Indispensable for …
2020年7月7日 · We found a significant increase in expression of p16 mRNA in Cd31-positive cells in 2-year-old mice (Figure 3 A). While most of the p16 mRNA expressions were detected in the …
P16为什么被称为抑癌基因 - promab.cn
2025年1月6日 · P16 全称为p16INK4a，是一种细胞周期调控蛋白。 它在细胞生长和分裂过程中的调控作用使它成为癌症研究中的关键。 P16的独特之处在于，它不仅是一个抑癌基因，还是一 …
Human umbilical cord-derived mesenchymal stem cells improve
3 天之前 · UC-MSCs mitigate the aging of the thymus and spleen by regulating aging-related genes. (a - d) p16, p53, p21, and RB mRNA levels in the thymus. (e – h) p16, p53, p21, and …
Analysis of HPV-16 viral load, integration status, and p16 ... - Nature
2025年3月11日 · The results regarding the relationship between P16 expression and HPV-16 integration status showed that the majority of samples with an episomal HPV-16 status …
细胞衰老过程中p16~ (INK4)mRNA稳定性调控
细胞衰老是诸多与之相关的基因或信号分子在环境因素作用下表达或修饰改变引起功能改变的“加合”结果.已发现至少上百个基因与衰老相关,但关键衰老相关基因的作用不可或缺.关键衰老相关基 …