细胞衰老的重要通路：p16 INK4a／Rb和p19 ARF／p53／p21 Cipl信号途径-细胞周期蛋白依赖激酶(cyclin-dependent kinase,CDK抑制因子p16 INK4a,p21 Cipl等是细胞衰老的关键效应物。

1998年9月10日 · The protein p19 ARF, one of the two tumoursuppressors encoded by the INK4a-ARF locus 8, activates p53 both by neutralizing MDM2, which destabilizes p53, and by interacting directly with p53...

2000年2月8日 · In immortal derivatives of cell lines expressing antisense p16INK4A or p19ARF RNA, growth arrest induced by recovery of p16 INK4A expression is bypassed by compromising the function of the...

2016年1月4日 · We therefore examined the role of p19 Arf in cellular responses to chronic, low-dose DNA-damaging agent treatment by maintaining MEFs in low oxygen and administering 0.5 G y γ-irradiation daily...

Role of the p19 ARF protein in checkpoint control. The p19 ARF protein (ARF) responds to proliferative signals normally required for cell proliferation. When these signals exceed a critical threshold, the ARF-dependent checkpoint (vertical barrel) is activated,

1997年11月28日 · In this issue of Cell, Kamijo and coworkers (1997) report that much of the phenotype ascribed to p16 -null mice may in fact be attributed to disruption of p19ARF, an alternatively spliced transcript derived from genomic sequence shared with the p16 transcript but encoding a different open reading frame.

1998年3月20日 · The INK4a gene encodes two distinct growth inhibitors—the cyclin-dependent kinase inhibitor p16 Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19 Arf, which has been functionally linked to p53.

1999年6月8日 · We show here that coexpression of p19 (ARF) blocks the nucleo-cytoplasmic shuttling of Mdm2. Moreover, subnuclear localization of Mdm2 changes from the nucleoplasm to the nucleolus in a shuttling time-dependent manner, whereas p19 (ARF) is exclusively located in …

2016年8月18日 · We therefore examined the role of p19 (Arf) in cellular responses to chronic, low-dose DNA-damaging agent treatment by maintaining MEFs in low oxygen and administering 0.5 G y γ-irradiation daily or 150 μM hydroxyurea, a replication stress inducer.

2004年1月15日 · We report the generation and characterization of a p19 (ARF)-specific knockout allele (p19 (ARF)-/-) and direct comparison with mice and derivative cells deficient for p16 (INK4a), both p16 (INK4a) and p19 (ARF), and p53.