Prophet 21 is a comprehensive enterprise resource planning (ERP) software designed for distributors to streamline operations and improve efficiency.

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.

We propose strategies to use p21 for intervening in cellular senescence by delaying aging, eliminating senescent cells, and rejuvenating them. Understanding the pathogenesis of p21-dependent senescence is crucial for studying aging heterogeneity and …

P21 is a peptide that targets neurogenesis and neurodegeneration. Studies show P21 rescued many structural deformities seen in the brains of autistic mice.

One of the main engines that drives cellular transformation is the loss of proper control of the mammalian cell cycle. The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli.

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.

2017年3月6日 · Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either triggers momentary G1 cell cycle arrest or leads to a chronic state of senescence or apoptosis, a form of genome guardianship.

p21 (WAF1/CIP1; CDKN1a) is a universal cell cycle inhibitor directly controlled by p53 and p53-independent pathways. Knowledge of the regulation and function of p21 in normal and cancer cells has opened up several areas of investigation and has led ...

p21 is an inhibitor of cyclin-dependent kinase and acts to prevent protein retinoblastoma (pRb) phosphorylation by inhibiting activation of cyclin E/cdk2 complexes that are required for Rb phosphorylation. Expression of p21 is regulated by a number of …

2016年6月1日 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.