2024年11月1日 · A p21 inhibitor alleviated the effects of FOXM1 inhibition on oxidative stress, mitochondrial function, and DNA damage and thus alleviated the degree of senescence in aging oocytes. These results indicate that FOXM1 plays a crucial role in porcine oocyte aging.

2022年3月31日 · In the current synopsis, the mechanism of regulation by p53-p21-RB signaling is assessed and the overlap with p53-p21-DREAM signaling is examined. The tumor suppressor p53 can induce cell cycle...

foxm1是一种已知的 原癌基因 ，与细胞增殖、细胞周期、细胞分化、dna损伤修复、组织稳态、凋亡和氧化还原信号转导有关，foxm1有促进组织再生的潜能，鉴于其促癌性已得到充分的研究，有必要在长期的研究中详细评估其潜在的致癌副作用，识别受影响的细胞 ...

2022年5月5日 · Here, we show that in vivo cyclic induction of an N-terminal truncated FOXM1 transgene on progeroid and naturally aged mice offsets aging-associated repression of full-length endogenous Foxm1,...

FoxM1 was stabilized in response to DNA damage in MEFs and FoxM1 overexpression induced p21. Knockdown of FoxM1 resulted in decrease in Chk1. ChIP, EMSA and cotransfection assays confirmed that FoxM1 stimulated promoters of p21 and Chk1. Conclusions: Chk1 and p21 are direct transcription targets of FoxM1 and FoxM1 participates in ...

OGT inhibition stabilizes p21 through the FoxM1–Skp2 pathway. p21 is known to be a target of different ubiquitin complexes, including the SCF-ubiquitin complex that contains Skp2 . FoxM1 is a key regulator of Skp2 mRNA transcription , and inhibition of OGT was reported to decrease FoxM1 expression and consequentially lower the levels of Skp2 .

FoxM1 was stabilized in response to DNA damage in MEFs and FoxM1 overexpression induced p21. Knockdown of FoxM1 resulted in decrease in Chk1. ChIP, EMSA and cotransfection assays confirmed that FoxM1 stimulated promoters of p21 and Chk1.

Forkhead box M1 (FoxM1) is essential for the development of various cancers and is a proliferation-specific transcription factor that regulates transcription of cell cycle genes, including cyclin-dependent kinase inhibitors p27(kip1) and p21(waf1/cip1) .

p21 抑制剂减轻了 foxm1 抑制对氧化应激、线粒体功能和 dna 损伤的影响，从而减轻了衰老卵母细胞的衰老程度。 这些结果表明，FOXM1 在猪卵母细胞衰老中起着至关重要的作用。

2009年9月14日 · This finding confirms the importance of p21 in FoxM1 regulation and also highlights a biological context in which precise regulation of FoxM1 levels is crucial to inhibition of proliferation.