Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

2024年12月24日 · Decreased levels of p27Kip1, mainly due to proteasomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate. Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues.

The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates cell proliferation, cell motility and apoptosis. Interestingly, the protein can exert both positive and...

p27 kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming growth factor (TGF)-β. Since the cloning of the p27 gene in 1994, a host of other functions have been associated with this cell cycle protein.

2021年8月31日 · The Cyclin-dependent kinase (CDK) regulator p27 Kip1 is a gatekeeper of G1/S transition. It also regulates G2/M progression and cytokinesis completion, via CDK-dependent or -independent mechanisms. Recently, other important p27 Kip1 functions have been described, including the re …

p27(Kip1) is an inhibitor of a broad spectrum of cyclin-dependent kinases (CDKs), and the loss of a single p27(Kip1) allele is thereby sufficient to increase tumor incidence via CDK-mediated cell cycle entry. As such, down-regulation of p27(Kip1) protein levels, in …

2007年1月21日 · We present evidence that the cyclin-dependent kinase inhibitor p27 Kip1, is phosphorylated at Thr 198 downstream of the Peutz-Jeghers syndrome protein–AMP-activated protein kinase (LKB1–AMPK)...

2021年6月8日 · Once believed to solely function as a cyclin-dependent kinase inhibitor, p27 Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis. During periods of metabolic stress, the subcellular location of …

2012年10月16日 · At the molecular level, p27 Kip1 is a microtubule-associated protein that promotes polymerization of microtubules in extending neurites, thereby contributing to tangential migration. Furthermore, we show that p27 Kip1 controls actomyosin contractions that drive both forward translocation of the nucleus and growth cone splitting.

2001年3月10日 · A major function of p27, also known as Kip1, is to bind and inhibit cyclin/cyclin-dependent kinase complexes, thereby blocking cell cycle progression. As p27 operates at the heart of the cell cycle, it is perhaps not surprising that it is emerging as a key player in multiple cell fate decisions including proliferation, differentiation, and cell ...