There are three known distinct classes of purinergic receptors, known as P1, P2X, and P2Y receptors. P2X receptors are ligand-gated ion channels, whereas the P1 and P2Y receptors are G protein-coupled receptors.

1996年5月3日 · The P 2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P 2X receptors, are permeable only to small cations.

2020年4月15日 · What is a P2Z file? Compressed pose file created with Poser, a 3D figure design program; may include information about figure joint angles, body position, and morph values; can be applied to Poser figures as well as entire scenes.

1996年5月3日 · The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P2X receptors, are permeable only to small cations.

the P2Z receptor in immune and inflammatory cells and, as a consequence, stimulated interest in the role of ATP, in the immune system. This article summarizes recent developments in the physiology and cell biology of the P2Z receptor in immune cells and …

1995年11月1日 · Many immune and inflammatory cells express a plasma membrane receptor for extracellular ATP, termed the P2Z purinoceptor, which appears to be coupled to a plasma membrane pore. The physiological role of such a molecule is generally unknown, except for the striking susceptibility to ATP-mediated cytotoxicity that it confers.

Many immune and inflammatory cells express a plasma membrane receptor for extracellular ATP, termed the P2Z purinoceptor, which appears to be coupled to a plasma membrane pore. The physiological role of such a molecule is generally unknown, except for the striking susceptibility to ATP-mediated cyto …

These data suggest that human macrophages express rIFN-gamma-modulated purinergic P2Z receptors in vitro and hint at a role for these plasma membrane molecules in the generation of macrophage polykarions. We have investigated responses of human monocyte/macrophage cells to extracellular ATP (ATPe).

1994年10月15日 · The present study shows that human mononuclear phagocytes express a P2Z- like purinergic membrane receptor activity.

1997年12月1日 · Millimolar concentrations of extracellular ATP (ATP o) can induce the permeabilization of plasma membranes of macrophages and other bone marrow-derived cells to low-molecular-weight solutes, a phenomenon that is the hallmark of P2Z purinoceptors.