P2X purinoceptor 4 is a protein that in humans is encoded by the P2RX4 gene. P2X purinoceptor 4 is a member of the P2X receptor family. [5][6][7] P2X receptors are trimeric protein complexes that can be homomeric or heteromeric. These receptors are ligand-gated cation channels that open in response to ATP binding. [8] .

2024年12月25日 · P2RX4 (Purinergic Receptor P2X 4) is a Protein Coding gene. Diseases associated with P2RX4 include Anxiety and Complex Regional Pain Syndrome. Among its related pathways are Platelet homeostasis and Infectious disease. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and monoatomic ion …

The P2X4 receptor, encoded by the P2RX4 gene, is a trimeric adenosine 5′-triphosphate (ATP)-gated cation channel that is expressed primarily in cells and tissues of the immune and central nervous systems where it has established roles primarily in …

2021年3月24日 · Extracellular nucleotides are important mediators of activation, triggering various responses through plasma membrane P2 and P1 receptors. P2 receptors are further subdivided into ionotropic P2X receptors and G protein-coupled P2Y receptors. P2X4 is an ATP-gated cation channel broadly expressed in most tissues of the body.

2024年2月14日 · We show that bone marrow plasma cells use the ligand-gated purinergic ion channel P2RX4 to sense extracellular ATP released by bone marrow osteoblasts through the gap-junction protein pannexin 3...

Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues. 该基因的产物属于 ATP 嘌呤受体家族。 该受体充当具有高钙渗透性的配体门控离子通道。 嘌呤受体家族成员之间的主要药理学区别是对拮抗剂苏拉明和 PPADS 的相对敏感性。 该基因的产物对这些拮抗剂的敏感性最低。 已发现该基因的多个选择性剪接转录物变体，一些编码蛋白质，一些不编码蛋白质。 [RefSeq 提供，2012 年 2 月] The product of this gene belongs to the family of …

purinergic receptor P2X 4 provided by HGNC. HGNC:HGNC:8535. Ensembl:ENSG00000135124 MIM:600846; AllianceGenome:HGNC:8535. protein coding. REVIEWED. P2X4; P2X4R. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability.

2025年2月8日 · findings suggest that P2X4 receptors are therapeutic targets for immunomodulation in transplantation and inflammatory diseases. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability.

Results found that P2X4R was highly expressed in glioblastoma multiforme cell lines. Its depletion suppressed cell survival and proliferation while promoting cell apoptosis through BDNF/TrkB/ATF4 signaling pathway. This study provides the first evidence that P2X4R plays important roles in GBM cell growth and apoptosis.

该基因编码的蛋白可启动细胞外 ATP 门控阳离子通道活动。 作用于多个过程的上游或内部，包括兴奋性突触后电位；一氧化氮生物合成过程；和血管扩张。 位于细胞顶端。 以多种结构表达，包括心血管系统；直觉;免疫系统;神经系统;和内脏颅骨。 与人 P2RX4（嘌呤能受体 P2X 4）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables extracellularly ATP-gated cation channel activity.