The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators): p300 (also called EP300 or E1A binding protein p300) CBP (also known as CREB-binding protein or CREBBP)

2007年3月20日 · CREB-binding protein (CBP) and its homologue p300 are transcriptional co-activators of various sequence-specific transcription factors that are involved in a wide array of cellular activities,...

2021年6月8日 · Recent efforts have identified specific and potent CBP/p300 inhibitors that target the acetyltransferase activity and the acetytllysine-binding bromodomain (BD) of CBP/p300. These compounds inhibit AR signaling and tumor growth in prostate cancer. CBP/p300 inhibitors may also be applicable for treating breast and other hormone-dependent cancers.

2021年3月9日 · 更多的活细胞成像数据暗示，TF/p300的共凝聚让p300以类似“all-or-none”的方式在空间位置上被激活，进而催化乙酰化修饰、招募Brd4，该招募强度与TF/p300形成共凝聚物的能力正相关。

2022年9月2日 · p300/cbp是肿瘤疾病的重要靶标之一，研究人员长期致力于设计和发现靶向 p300/cbp的优质小分子抑制剂。 根据作用位点的不同，当下的抑制剂化合物的研究主要是从BRD结构域、HAT结构域这两个功能域进行抑制的方法来干扰p300/CBP的功能。

2001年8月1日 · Phosphorylation of CREB family members promotes target gene expression through the recruitment of the coactivator CREB-binding protein (CBP) and its paralogue p300. Phosphorylation of CREB at ...

p300/CBP(CREB Binding Protein, CBP)是多功能的转录辅激活子, 它们参与细胞周期调控、细胞分化和细胞凋亡等多种生理过程. p300/CBP具有乙酰转移酶活性, 能通过乙酰化组蛋白和非组蛋白的方式参与基因的转录调控, 同时, 它们能在转录因子和基本转录复合物之间起到桥梁 ...

2018年7月4日 · CREB binding protein (CBP) and its close paralogue p300 are transcriptional coactivators with intrinsic acetyltransferase activity. Both CBP/p300 play critical roles in development and diseases. The enzymatic and biological functions of CBP/p300 are tightly regulated by themselves and by external factors.

CREB 1-binding protein (CBP) and p300 are believed to participate in the activities of hundreds of different transcription factors (see Fig.1). Current models suggest that the binding of these coactivators to transcription factor activation domains positions histone acetyltransferases (HATs) near specific nucleosomes in target gene promoter ...

p300/CBP参与细胞周期进展和细胞的生长、分化和发展，是一类非常重要的辅激活因子，可以调节多种关键转录调节因子的功能。p300/CBP与多种肿瘤疾病密切相关，是一个极具应用前景的肿瘤治疗靶标。