Poloxamer 407 (F127) (Synonyms: 泊洛沙姆 407 (F127); PEG-PPG …
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, …
Developing a model to predict the early risk of …
2023年12月19日 · A preclinical LPL-dependent model of HTG was developed using a single intraperitoneal injection of poloxamer 407 (P407) in male Wistar rats.
Regulation of plasma lipid homeostasis by hepatic lipoprotein lipase …
2016年7月1日 · LPL Δhep mice showed a similar response of plasma TG accumulation as control mice after P407 injection (Fig. 5B), indicative of their normal hepatic TG secretion. Taken …
Poloxamer 407 as a general lipase inhibitor: its implications ... - PubMed
Key findings: Endothelial lipase was expressed using a recombinant adenovirus; subconfluent COS cells were exposed to recombinant adenoviruses and triglyceride lipase activity was …
Gualou Xiebai Banxia decoction ameliorates Poloxamer 407-induced ...
2021年6月25日 · Results: The GLXBBX decoction significantly improved P407-induced hyperlipidemia, including increased plasma triglycerides (TGs), aspartate aminotransferase …
辅料泊洛沙姆407作用与应用.doc-全文可读 - 原创力文档
研究发现，P407能够抑制LPL的释放（P407浓度350 μmol/L时，可完全抑制LPL的释放）；而LPL是催化三酰甘油水解的关键步骤酶，抑制LPL，必将导致三酰甘油水解率减慢，从而诱发 …
泊洛沙姆407（P-407）诱导的金黄地鼠脂代谢紊乱模型-
P-407能够上调金黄地鼠肝脏中HMG-CoA还原酶的mRNA表达水平，并下调LCAT的表达水平，干扰了胆固醇的合成和酯化的关键途径，从而引起脂质代谢紊乱。 SPF级雄性金黄地鼠。 采用 …
<br>阳桃叶可预防泊洛沙姆 407 诱导的急性高脂血 ... - X-MOL
泊洛沙姆-407 (P-407) 诱导大鼠急性高脂血症，并口服不同组分的 MEACL（正己烷、氯仿、正丁醇、乙酸乙酯 (EA)、水和氯仿）。 在 0、12、24 和 48 小时测定胆固醇和甘油三酯，48 小时 …
Poloxamer 407 Induces Hypertriglyceridemia but Decreases ...
2022年5月30日 · Results: Compared with the saline control, P407 injection in Ldlr -/- mice rapidly induced profound and persistent HTG, modestly elevated plasma cholesterol levels, and …
Gualou Xiebai Banxia decoction ameliorates Poloxamer 407 …
2021年6月6日 · Results: The GLXBBX decoction significantly improved P407-induced hyperlipidemia, including increased plasma triglycerides (TGs), aspartate aminotransferase …