2017年12月1日 · Stability of p53 is regulated by the ubiquitin-proteasome pathway (UPP). Furthermore, it is readjusted by deubiquitination via deubiquitinating enzymes (DUBs) that can …

USP10 is identified as a cytoplasmic DUB that regulates p53 levels and localization by reversing Mdm2-induced p53 nuclear export and degradation. It regulates the stability of p53 without …

该途径也是一种动态的蛋白质双向修饰调控系统，在体内由 泛素连接酶系统 （E1-E2-E3）对底物进行泛素化修饰，去泛素化酶（DUB）家族负责通过水解泛素羧基末端的酯键、肽键或异肽 …

In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. OTUD5 forms a direct complex with p53 and controls level of ubiquitination. The function of …

2014年5月26日 · A number of deubiquitinating enzymes (DUBs) from the ubiquitin-specific protease family have been shown to regulate the p53-MDM2-MDMX networks. We recently …

2024年6月30日 · Here, using small-molecule microarray-based technology and unbiased screening, we identified three potential molecular glues that may tether P53 to the DUB, …

2013年10月15日 · Principal findings: In this study, we have identified OTUD5 as a DUB that interacts with and deubiquitinates p53. OTUD5 forms a direct complex with p53 and controls …

2025年3月11日 · In this study, we demonstrated the involvement of DUBs—USP5 and USP9X in—enhancing mutp53 stability while revealing the effects of DUB inhibitor WP1130 in …

Abstract as emerged as an important mecha-nism of p53 regulation. A number of deubiquitinating enzymes (DUBs) from the ubiquitin-specific protease famil have been shown to regulate the …

2025年3月11日 · In gastric cancer cells harbouring p53 mutations, ovarian tumour domain-containing 5 (OTUD5) transcription is upregulated due to the inactivation of p53, allowing …