2025年2月18日 · we identified brain mitochondrial proteins in p53 null mice that display crucial p53-dependent cellular functions in the central nervous system. Met synergizes with p53 loss …

Studies in mice have yielded invaluable insight into our understanding of the p53 pathway. Mouse models with activated p53, no p53, and mutant p53 have queried the role of p53 in …

2024年3月21日 · We find that p53, a central regulator of the cellular response to DNA damage, regulates tissue dysfunction in Ercc1-/- mice in different ways. We show that ablation of p53 …

2013年1月14日 · Here, we review studies utilizing p53 mutant mice that have recapitulated and informed clinical observations. These studies have demonstrated the p53 contribution, …

The p53-deficient mice have been particularly valuable in examining the effects of p53 loss on tumor progression. In addition, the mice hold significant promise as tools to assess …

2025年2月11日 · This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA …

In this review, we detail a variety of p53 mouse models that have advanced our understanding of various aspects of p53 biology, including how p53 tumor mutants not only promote loss-of …

2009年9月24日 · These mouse studies have been instrumental in providing important new insights into p53 tumour suppressor function. Such studies have been facilitated by the …

Monoclonal Antibody for studying p53. Validated for ChIP, F, IF, IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, p53 (1C12) Mouse Monoclonal Antibody …

Here, we discuss how genetically engineered mouse models have been used to explore antiproliferative functions of p53 in cancer suppression and how mouse models with altered …