2023年3月1日 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …

The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have …

p53 pathway: In a normal cell, p53 is inactivated by its negative regulator, mdm2. Upon DNA damage or other stresses, various pathways will lead to the dissociation of the p53 and mdm2 …

p53具有典型的转录激活蛋白结构域. p53蛋白是调控转录的序列特异性DNA结合蛋白。p53蛋白由两个N-末端反式激活结构域组成，其后是保守的富含脯氨酸结构域，中央DNA结合结构域和编 …

p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53 …

2005年4月18日 · There are at least seven negative and three positive feedback loops described here, and of these, six act through the MDM-2 protein to regulate p53 activity. The p53 circuit …

The p53 pathway is a major tumor suppressor pathway that prevents the propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or senescence. The multiple …

2016年6月2日 · Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually every tumor. In …

2025年2月11日 · The p53 signaling pathway is essential for maintaining cellular integrity and preventing tumorigenesis by regulating cell cycle progression, DNA repair, apoptosis, and …

Apoptosis and senescence are the main pathways by which p53 inhibits tumors. Normal p53 can monitor and identify DNA damage points. For damaged DNA, p53 prevents DNA replication …