The p53 Core Domain Is a Molten Globule at Low pH - PMC
2010年1月1日 · p53 is a transcription factor that maintains genome integrity, and its function is lost in 50% of human cancers. The majority of p53 mutations are clustered within the core …
Effect of pH on radiation-induced p53 expression - PubMed
2004年11月15日 · Cells grown in pH 7.5 medium or pH 6.6 medium were irradiated with gamma-rays, and the expression of p53 and p53 mRNA, as well as the degradation rate of the …
Effect of pH on radiation-induced p53 expression - ScienceDirect
2004年11月15日 · The pH 6.6 environment prolonged the radiation-induced expression of p53 and p53 mRNA. The radiation-induced increase in transcriptional activity of p53 lasted longer …
An acidic environment leads to p53 dependent induction of
1999年5月25日 · As tumours are known to acidify their microenvironment and fluctuations in lumenal pH have been reported in a number of colonic disease conditions, we investigated …
Inactivation of p53 Is Sufficient to Induce Development of
2015年6月29日 · Pharmacological inactivation of p53 is sufficient to induce PH with a chronic treatment by PFT, an effect related to its anti-apoptotic and pro-proliferative properties. The …
PO-101 P53 core domain activity at low PH - ScienceDirect
2018年6月30日 · We describe the interaction of DNA and p53 at several pH (5.0, 5.5, 6.0, 6.5, 7.2) using fluorescence anisotropy. We confirm the formation of p53C:DNA complex under the …
The p53 core domain is a molten globule at low pH: functional
2010年1月22日 · p53 is a transcription factor that maintains genome integrity, and its function is lost in 50% of human cancers. The majority of p53 mutations are clustered within the core …
PO-101 P53 core domain activity at low PH - ESMO Open
2018年6月30日 · We describe the interaction of DNA and p53 at several pH (5.0, 5.5, 6.0, 6.5, 7.2) using fluorescence anisotropy. We confirm the formation of p53C:DNA complex under the …
The regulation of p53 by phosphorylation: a model for how …
The tumour suppressor p53 is a transcription factor that has evolved the ability to integrate distinct environmental signals including DNA damage, virus infection, and cytokine signaling into a …
Nucleo-cytoplasmic environment modulates spatiotemporal p53 …
2024年12月11日 · Here, using cellular models and in vitro studies, we show the spatiotemporal formation and material properties of p53 condensates that might dictate its function. In …