Crosstalk between p53 and TGF-β Signalling - PubMed
Wild-type p53 and Smads physically interact and coordinately induce transcription of a number of key tumour suppressive genes. Conversely mutant p53 generally subverts tumour suppressive …
Links between tumor suppressors: p53 is required for TGF-beta …
2003年5月2日 · Smad and p53 protein complexes converge on separate cis binding elements on a target promoter and synergistically activate TGF-beta induced transcription. p53 can …
TGF-β induces p53/Smads complex formation in the - Nature
2016年10月19日 · Here we show that the tumor suppressor p53 cooperates with Smad proteins, which are TGF-β signal transducers, to selectively activate plasminogen activator inhibitor type …
Crosstalk between p53 and TGF-β Signalling - PMC
Wild-type p53 and TGF-β are key tumour suppressors which regulate an array of cellular responses. TGF-β signals in part via the Smad signal transduction pathway. Wild-type p53 …
TGF-β induces p53/Smads complex formation in the PAI-1 ... - PubMed
2016年10月19日 · Here we show that the tumor suppressor p53 cooperates with Smad proteins, which are TGF-β signal transducers, to selectively activate plasminogen activator inhibitor type …
Coordinate Transcriptional and Translational Repression of p53 by TGF ...
2013年5月23日 · We demonstrate that TGF-β1 signaling interferes with the stress response through coordinate transcriptional and translational repression of p53 levels, which reduces …
Differential regulation of the REGγ–proteasome pathway by p53/TGF …
2013年10月25日 · REGγ, a proteasome activator known to promote p53/p21/p16 degradation, is often overexpressed in cancer cells. Here we show that p53/TGF-β signalling inhibits the …
TGF-β upregulates the translation of USP15 via the PI3K/AKT
2016年11月28日 · In the current study, we identify that USP15 binds to and stabilizes p53 through deubiquitination in U2OS and HEK293 cells. TGF-β promotes the translation of USP15 …
p53与TGF-β通路相关性的研究进展-【维普期刊官网】- 中文期刊 …
突变型p53丧失了野生型p53的正常功能,能促进细胞增殖转化而且具有致癌作用。 TGF-β超家族信号通路广泛参与胚胎发育,细胞增殖、分化、迁移和凋亡,创伤修复。 P53与TGF-β通路之间有 …
Links between Tumor Suppressors: p53 Is Required for TGF-β …
2003年5月2日 · Smad and p53 protein complexes converge on separate cis binding elements on a target promoter and synergistically activate TGF-β induced transcription. p53 can physically …